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Physical activity mediates the association between personality and biomarkers of inflammation.

SAGE open medicine

Graham EK, Bastarache ED, Milad E, Turiano NA, Cotter KA, Mroczek DK.
PMID: 29796267
SAGE Open Med. 2018 May 15;6:2050312118774990. doi: 10.1177/2050312118774990. eCollection 2018.

OBJECTIVES: The current study investigated whether personality traits and facets were associated with interleukin-6, C-reactive protein, and fibrinogen, and whether physical activity mediated the relationship between personality and biomarkers of inflammation.METHODS: Personality was assessed in the Midlife Development in...

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Graham EK, Bastarache ED, Milad E, et al. Physical activity mediates the association between personality and biomarkers of inflammation. SAGE Open Med. 2018;6:2050312118774990doi: 10.1177/2050312118774990.
Graham, E. K., Bastarache, E. D., Milad, E., Turiano, N. A., Cotter, K. A., & Mroczek, D. K. (2018). Physical activity mediates the association between personality and biomarkers of inflammation. SAGE open medicine, 62050312118774990. https://doi.org/10.1177/2050312118774990
Graham, Eileen K, et al. "Physical activity mediates the association between personality and biomarkers of inflammation." SAGE open medicine vol. 6 (2018): 2050312118774990. doi: https://doi.org/10.1177/2050312118774990
Graham EK, Bastarache ED, Milad E, Turiano NA, Cotter KA, Mroczek DK. Physical activity mediates the association between personality and biomarkers of inflammation. SAGE Open Med. 2018 May 15;6:2050312118774990. doi: 10.1177/2050312118774990. eCollection 2018. PMID: 29796267; PMCID: PMC5956639.
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Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU.

Critical care explorations

Kerchberger VE, Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, Bastarache JA, Ware LB.
PMID: 34250497
Crit Care Explor. 2021 Jul 06;3(7):e0457. doi: 10.1097/CCE.0000000000000457. eCollection 2021 Jul.

Acute respiratory distress syndrome is underrecognized in the ICU, but it remains uncertain if acute respiratory distress syndrome recognition affects evidence-based acute respiratory distress syndrome care in the modern era. We sought to determine the rate of clinician-recognized acute...

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Kerchberger VE, Brown RM, Semler MW, et al. Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU. Crit Care Explor. 2021;3(7):e0457doi: 10.1097/CCE.0000000000000457.
Kerchberger, V. E., Brown, R. M., Semler, M. W., Zhao, Z., Koyama, T., Janz, D. R., Bastarache, J. A., & Ware, L. B. (2021). Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU. Critical care explorations, 3(7), e0457. https://doi.org/10.1097/CCE.0000000000000457
Kerchberger, V Eric, et al. "Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU." Critical care explorations vol. 3,7 (2021): e0457. doi: https://doi.org/10.1097/CCE.0000000000000457
Kerchberger VE, Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, Bastarache JA, Ware LB. Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU. Crit Care Explor. 2021 Jul 06;3(7):e0457. doi: 10.1097/CCE.0000000000000457. eCollection 2021 Jul. PMID: 34250497; PMCID: PMC8263322.
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Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome.

JCI insight

Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP.
PMID: 34874923
JCI Insight. 2021 Dec 07; doi: 10.1172/jci.insight.154573. Epub 2021 Dec 07.

Acute Respiratory Distress Syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycocalyx, a layer of glycosaminoglycans interposed between...

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Rizzo AN, Haeger SM, Oshima K, et al. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2021;doi: 10.1172/jci.insight.154573.
Rizzo, A. N., Haeger, S. M., Oshima, K., Yang, Y., Wallbank, A. M., Jin, Y., Lettau, M., McCaig, L. A., Wickersham, N. E., McNeil, J. B., Zakharevich, I., McMurtry, S. A., Langouët-Astrié, C. J., Kopf, K. W., Voelker, D. R., Hansen, K. C., Shaver, C. M., Kerchberger, V. E., Peterson, R. A., Kuebler, W. M., Ochs, M., Veldhuizen, R. A., Smith, B. J., Ware, L. B., Bastarache, J. A., & Schmidt, E. P. (2021). Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI insight, . https://doi.org/10.1172/jci.insight.154573
Rizzo, Alicia N, et al. "Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome." JCI insight vol. (2021). doi: https://doi.org/10.1172/jci.insight.154573
Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2021 Dec 07; doi: 10.1172/jci.insight.154573. Epub 2021 Dec 07. PMID: 34874923.
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Promoting our early career members at .

American journal of physiology. Lung cellular and molecular physiology

Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE.
PMID: 34585617
Am J Physiol Lung Cell Mol Physiol. 2021 Nov 01;321(5):L844-L846. doi: 10.1152/ajplung.00389.2021. Epub 2021 Sep 29.

No abstract available.

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Shimoda LA, Bai C, Bartlett NW, et al. Promoting our early career members at . Am J Physiol Lung Cell Mol Physiol. 2021;321(5):L844-L846doi: 10.1152/ajplung.00389.2021.
Shimoda, L. A., Bai, C., Bartlett, N. W., Bastarache, J. A., Feghali-Bostwick, C., Gunst, S. J., Kuebler, W. M., Schmidt, E. P., & Morty, R. E. (2021). Promoting our early career members at . American journal of physiology. Lung cellular and molecular physiology, 321(5), L844-L846. https://doi.org/10.1152/ajplung.00389.2021
Shimoda, Larissa A, et al. "Promoting our early career members at ." American journal of physiology. Lung cellular and molecular physiology vol. 321,5 (2021): L844-L846. doi: https://doi.org/10.1152/ajplung.00389.2021
Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at . Am J Physiol Lung Cell Mol Physiol. 2021 Nov 01;321(5):L844-L846. doi: 10.1152/ajplung.00389.2021. Epub 2021 Sep 29. PMID: 34585617; PMCID: PMC8616620.
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Eyes wide open on bronchial aeration in acute respiratory distress syndrome.

Anaesthesia, critical care & pain medicine

Jabaudon M, Bastarache JA, Ware LB.
PMID: 32145431
Anaesth Crit Care Pain Med. 2020 Apr;39(2):191-192. doi: 10.1016/j.accpm.2020.03.003. Epub 2020 Mar 04.

No abstract available.

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Jabaudon M, Bastarache JA, Ware LB. Eyes wide open on bronchial aeration in acute respiratory distress syndrome. Anaesth Crit Care Pain Med. 2020;39(2):191-192doi: 10.1016/j.accpm.2020.03.003.
Jabaudon, M., Bastarache, J. A., & Ware, L. B. (2020). Eyes wide open on bronchial aeration in acute respiratory distress syndrome. Anaesthesia, critical care & pain medicine, 39(2), 191-192. https://doi.org/10.1016/j.accpm.2020.03.003
Jabaudon, Matthieu, et al. "Eyes wide open on bronchial aeration in acute respiratory distress syndrome." Anaesthesia, critical care & pain medicine vol. 39,2 (2020): 191-192. doi: https://doi.org/10.1016/j.accpm.2020.03.003
Jabaudon M, Bastarache JA, Ware LB. Eyes wide open on bronchial aeration in acute respiratory distress syndrome. Anaesth Crit Care Pain Med. 2020 Apr;39(2):191-192. doi: 10.1016/j.accpm.2020.03.003. Epub 2020 Mar 04. PMID: 32145431.
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Sepsis.

Clinics in chest medicine

Bastarache JA, Seeley EJ.
PMID: 27229652
Clin Chest Med. 2016 Jun;37(2):xv-xvi. doi: 10.1016/j.ccm.2016.04.001.

No abstract available.

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Bastarache JA, Seeley EJ. Sepsis. Clin Chest Med. 2016;37(2):xv-xvidoi: 10.1016/j.ccm.2016.04.001.
Bastarache, J. A., & Seeley, E. J. (2016). Sepsis. Clinics in chest medicine, 37(2), xv-xvi. https://doi.org/10.1016/j.ccm.2016.04.001
Bastarache, Julie A, and Seeley, Eric J. "Sepsis." Clinics in chest medicine vol. 37,2 (2016): xv-xvi. doi: https://doi.org/10.1016/j.ccm.2016.04.001
Bastarache JA, Seeley EJ. Sepsis. Clin Chest Med. 2016 Jun;37(2):xv-xvi. doi: 10.1016/j.ccm.2016.04.001. PMID: 27229652.
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Advancing precision medicine for acute respiratory distress syndrome.

The Lancet. Respiratory medicine

Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS.
PMID: 34310901
Lancet Respir Med. 2021 Jul 23; doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23.

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have...

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Beitler JR, Thompson BT, Baron RM, et al. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021;doi: 10.1016/S2213-2600(21)00157-0.
Beitler, J. R., Thompson, B. T., Baron, R. M., Bastarache, J. A., Denlinger, L. C., Esserman, L., Gong, M. N., LaVange, L. M., Lewis, R. J., Marshall, J. C., Martin, T. R., McAuley, D. F., Meyer, N. J., Moss, M., Reineck, L. A., Rubin, E., Schmidt, E. P., Standiford, T. J., Ware, L. B., Wong, H. R., Aggarwal, N. R., & Calfee, C. S. (2021). Advancing precision medicine for acute respiratory distress syndrome. The Lancet. Respiratory medicine, . https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler, Jeremy R, et al. "Advancing precision medicine for acute respiratory distress syndrome." The Lancet. Respiratory medicine vol. (2021). doi: https://doi.org/10.1016/S2213-2600(21)00157-0
Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021 Jul 23; doi: 10.1016/S2213-2600(21)00157-0. Epub 2021 Jul 23. PMID: 34310901; PMCID: PMC8302189.
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A phenome-wide association study to discover pleiotropic effects of .

NPJ genomic medicine

Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, Rasmussen-Torvik LJ, Pendergrass SA, Sturm AC, Namjou B, Shah AS, Carroll RJ, Chung WK, Wei WQ, Feng Q, Stein CM, Roden DM, Manolio TA, Schaid DJ, Denny JC, Hebbring SJ, de Andrade M, Kullo IJ.
PMID: 30774981
NPJ Genom Med. 2019 Feb 11;4:3. doi: 10.1038/s41525-019-0078-7. eCollection 2019.

We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genes

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Safarova MS, Satterfield BA, Fan X, et al. A phenome-wide association study to discover pleiotropic effects of . NPJ Genom Med. 2019;4:3doi: 10.1038/s41525-019-0078-7.
Safarova, M. S., Satterfield, B. A., Fan, X., Austin, E. E., Ye, Z., Bastarache, L., Zheng, N., Ritchie, M. D., Borthwick, K. M., Williams, M. S., Larson, E. B., Scrol, A., Jarvik, G. P., Crosslin, D. R., Leppig, K., Rasmussen-Torvik, L. J., Pendergrass, S. A., Sturm, A. C., Namjou, B., Shah, A. S., Carroll, R. J., Chung, W. K., Wei, W. Q., Feng, Q., Stein, C. M., Roden, D. M., Manolio, T. A., Schaid, D. J., Denny, J. C., Hebbring, S. J., de Andrade, M., & Kullo, I. J. (2019). A phenome-wide association study to discover pleiotropic effects of . NPJ genomic medicine, 43. https://doi.org/10.1038/s41525-019-0078-7
Safarova, Maya S, et al. "A phenome-wide association study to discover pleiotropic effects of ." NPJ genomic medicine vol. 4 (2019): 3. doi: https://doi.org/10.1038/s41525-019-0078-7
Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, Rasmussen-Torvik LJ, Pendergrass SA, Sturm AC, Namjou B, Shah AS, Carroll RJ, Chung WK, Wei WQ, Feng Q, Stein CM, Roden DM, Manolio TA, Schaid DJ, Denny JC, Hebbring SJ, de Andrade M, Kullo IJ. A phenome-wide association study to discover pleiotropic effects of . NPJ Genom Med. 2019 Feb 11;4:3. doi: 10.1038/s41525-019-0078-7. eCollection 2019. PMID: 30774981; PMCID: PMC6370860.
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Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation.

The Journal of clinical investigation

Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Newcomb DC.
PMID: 35025767
J Clin Invest. 2022 Jan 13; doi: 10.1172/JCI153397. Epub 2022 Jan 13.

Women have higher prevalence of asthma compared to men. In asthma, allergic airway inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and IL-13 production and eosinophil infiltration. Foxp3+ Tregs suppress and ST2+ Tregs promote...

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Gandhi VD, Cephus JY, Norlander AE, et al. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022;doi: 10.1172/JCI153397.
Gandhi, V. D., Cephus, J. Y., Norlander, A. E., Chowdhury, N. U., Zhang, J., Ceneviva, Z. J., Tannous, E., Polosukhin, V. V., Putz, N. D., Wickersham, N., Singh, A., Ware, L. B., Bastarache, J. A., Shaver, C. M., Chu, H. W., Peebles, R. S., & Newcomb, D. C. (2022). Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. The Journal of clinical investigation, . https://doi.org/10.1172/JCI153397
Gandhi, Vivek D, et al. "Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation." The Journal of clinical investigation vol. (2022). doi: https://doi.org/10.1172/JCI153397
Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Newcomb DC. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022 Jan 13; doi: 10.1172/JCI153397. Epub 2022 Jan 13. PMID: 35025767.
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PhenomeXcan: Mapping the genome to the phenome through the transcriptome.

Science advances

Pividori M, Rajagopal PS, Barbeira A, Liang Y, Melia O, Bastarache L, Park Y, Consortium G, Wen X, Im HK.
PMID: 32917697
Sci Adv. 2020 Sep 10;6(37). doi: 10.1126/sciadv.aba2083. Print 2020 Sep.

Large-scale genomic and transcriptomic initiatives offer unprecedented insight into complex traits, but clinical translation remains limited by variant-level associations without biological context and lack of analytic resources. Our resource, PhenomeXcan, synthesizes 8.87 million variants from genome-wide association study summary...

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Pividori M, Rajagopal PS, Barbeira A, et al. PhenomeXcan: Mapping the genome to the phenome through the transcriptome. Sci Adv. 2020;6(37)doi: 10.1126/sciadv.aba2083.
Pividori, M., Rajagopal, P. S., Barbeira, A., Liang, Y., Melia, O., Bastarache, L., Park, Y., Consortium, G., Wen, X., & Im, H. K. (2020). PhenomeXcan: Mapping the genome to the phenome through the transcriptome. Science advances, 6(37), . https://doi.org/10.1126/sciadv.aba2083
Pividori, Milton, et al. "PhenomeXcan: Mapping the genome to the phenome through the transcriptome." Science advances vol. 6,37 (2020). doi: https://doi.org/10.1126/sciadv.aba2083
Pividori M, Rajagopal PS, Barbeira A, Liang Y, Melia O, Bastarache L, Park Y, Consortium G, Wen X, Im HK. PhenomeXcan: Mapping the genome to the phenome through the transcriptome. Sci Adv. 2020 Sep 10;6(37). doi: 10.1126/sciadv.aba2083. Print 2020 Sep. PMID: 32917697.
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Aggregating Electronic Health Record Data for COVID-19 Research-Caveat Emptor.

JAMA network open

Brown JS, Bastarache L, Weiner MG.
PMID: 34255055
JAMA Netw Open. 2021 Jul 01;4(7):e2117175. doi: 10.1001/jamanetworkopen.2021.17175.

No abstract available.

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Brown JS, Bastarache L, Weiner MG. Aggregating Electronic Health Record Data for COVID-19 Research-Caveat Emptor. JAMA Netw Open. 2021;4(7):e2117175doi: 10.1001/jamanetworkopen.2021.17175.
Brown, J. S., Bastarache, L., & Weiner, M. G. (2021). Aggregating Electronic Health Record Data for COVID-19 Research-Caveat Emptor. JAMA network open, 4(7), e2117175. https://doi.org/10.1001/jamanetworkopen.2021.17175
Brown, Jeffrey S, et al. "Aggregating Electronic Health Record Data for COVID-19 Research-Caveat Emptor." JAMA network open vol. 4,7 (2021): e2117175. doi: https://doi.org/10.1001/jamanetworkopen.2021.17175
Brown JS, Bastarache L, Weiner MG. Aggregating Electronic Health Record Data for COVID-19 Research-Caveat Emptor. JAMA Netw Open. 2021 Jul 01;4(7):e2117175. doi: 10.1001/jamanetworkopen.2021.17175. PMID: 34255055.
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Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation.

The Journal of clinical investigation

Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Newcomb DC.
PMID: 35025767
J Clin Invest. 2022 Jan 13; doi: 10.1172/JCI153397. Epub 2022 Jan 13.

Women have higher prevalence of asthma compared to men. In asthma, allergic airway inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and IL-13 production and eosinophil infiltration. Foxp3+ Tregs suppress and ST2+ Tregs promote...

Cite
Gandhi VD, Cephus JY, Norlander AE, et al. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022;doi: 10.1172/JCI153397.
Gandhi, V. D., Cephus, J. Y., Norlander, A. E., Chowdhury, N. U., Zhang, J., Ceneviva, Z. J., Tannous, E., Polosukhin, V. V., Putz, N. D., Wickersham, N., Singh, A., Ware, L. B., Bastarache, J. A., Shaver, C. M., Chu, H. W., Peebles, R. S., & Newcomb, D. C. (2022). Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. The Journal of clinical investigation, . https://doi.org/10.1172/JCI153397
Gandhi, Vivek D, et al. "Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation." The Journal of clinical investigation vol. (2022). doi: https://doi.org/10.1172/JCI153397
Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Newcomb DC. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022 Jan 13; doi: 10.1172/JCI153397. Epub 2022 Jan 13. PMID: 35025767.
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Showing 1 to 12 of 48 entries