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Wan H, Gu C, Gan Y, et al. Sensor-free and Sensor-based Heart-on-a-chip Platform: A Review of Design and Applications. Curr Pharm Des. 2018;24(45):5375-5385doi: 10.2174/1381612825666190207170004.
Wan, H., Gu, C., Gan, Y., Wei, X., Zhu, K., Hu, N., & Wang, P. (2018). Sensor-free and Sensor-based Heart-on-a-chip Platform: A Review of Design and Applications. Current pharmaceutical design, 24(45), 5375-5385. https://doi.org/10.2174/1381612825666190207170004
Wan, Hao, et al. "Sensor-free and Sensor-based Heart-on-a-chip Platform: A Review of Design and Applications." Current pharmaceutical design vol. 24,45 (2018): 5375-5385. doi: https://doi.org/10.2174/1381612825666190207170004
Wan H, Gu C, Gan Y, Wei X, Zhu K, Hu N, Wang P. Sensor-free and Sensor-based Heart-on-a-chip Platform: A Review of Design and Applications. Curr Pharm Des. 2018;24(45):5375-5385. doi: 10.2174/1381612825666190207170004. PMID: 30734671.
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Curr Pharm Des. 2018;24(45):5375-5385. doi: 10.2174/1381612825666190207170004.

Sensor-free and Sensor-based Heart-on-a-chip Platform: A Review of Design and Applications.

Current pharmaceutical design

Hao Wan, Chenlei Gu, Ying Gan, Xinwei Wei, Kai Zhu, Ning Hu, Ping Wang

Affiliations

  1. Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
  2. State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai 200050, China.
  3. Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  4. Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.

PMID: 30734671 DOI: 10.2174/1381612825666190207170004

Abstract

Drug efficacy and toxicity are key factors of drug development. Conventional 2D cell models or animal models have their limitations for the efficacy or toxicity assessment in preclinical assays, which induce the failure of candidate drugs or withdrawal of approved drugs. Human organs-on-chips (OOCs) emerged to present human-specific properties based on their 3D bioinspired structures and functions in the recent decade. In this review, the basic definition and superiority of OOCs will be introduced. Moreover, a specific OOC, heart-on-achip (HOC) will be focused. We introduce HOC modeling in the sensor-free and sensor-based way and illustrate the advantages of sensor-based HOC in detail by taking examples of recent studies. We provide a new perspective on the integration of HOC technology and biosensing to develop a new sensor-based HOC platform.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Keywords: 2D cell models; Human organs-on-chips; biomaterial; intracellular/extracellular recording; sensor-free/sensor-based heart-on-a-chip; synchronized electromechanical integration recording.

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