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Zhong L, Tong Y, Chuan J, et al. Protective effect of ethyl vanillin against Aβ-induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis. Exp Ther Med. 2019;17(4):2666-2674doi: 10.3892/etm.2019.7242.
Zhong, L., Tong, Y., Chuan, J., Bai, L., Shi, J., & Zhu, Y. (2019). Protective effect of ethyl vanillin against Aβ-induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis. Experimental and therapeutic medicine, 17(4), 2666-2674. https://doi.org/10.3892/etm.2019.7242
Zhong, Lei, et al. "Protective effect of ethyl vanillin against Aβ-induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis." Experimental and therapeutic medicine vol. 17,4 (2019): 2666-2674. doi: https://doi.org/10.3892/etm.2019.7242
Zhong L, Tong Y, Chuan J, Bai L, Shi J, Zhu Y. Protective effect of ethyl vanillin against Aβ-induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis. Exp Ther Med. 2019 Apr;17(4):2666-2674. doi: 10.3892/etm.2019.7242. Epub 2019 Feb 04. PMID: 30930969; PMCID: PMC6425458.
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Exp Ther Med. 2019 Apr;17(4):2666-2674. doi: 10.3892/etm.2019.7242. Epub 2019 Feb 04.

Protective effect of ethyl vanillin against Aβ-induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis.

Experimental and therapeutic medicine

Lei Zhong, Yuna Tong, Junlan Chuan, Lan Bai, Jianyou Shi, Yuxuan Zhu

Affiliations

  1. Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.
  2. Department of Nephrology, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, P.R. China.

PMID: 30930969 PMCID: PMC6425458 DOI: 10.3892/etm.2019.7242

Abstract

Increased aggregation of β-amyloid (Aβ) peptides induces oxidative stress, which is considered a major contributor in the development of Alzheimer's disease (AD). Prevention of Aβ-induced neurotoxicity is proposed as a possible modality for treatment of AD. The present study aimed to elucidate possible effects of ethyl vanillin (EVA), an analog of vanillin isolated from vanilla beans, on the Aβ

Keywords: ethyl vanillin; neuroprotection; oxidative stress

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