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Gallego-Martin T, Prieto-Lloret J, Aaronson PI, et al. Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells. Antioxidants (Basel). 2019;8(3)doi: 10.3390/antiox8030062.
Gallego-Martin, T., Prieto-Lloret, J., Aaronson, P. I., Rocher, A., & Obeso, A. (2019). Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells. Antioxidants (Basel, Switzerland), 8(3), . https://doi.org/10.3390/antiox8030062
Gallego-Martin, Teresa, et al. "Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells." Antioxidants (Basel, Switzerland) vol. 8,3 (2019). doi: https://doi.org/10.3390/antiox8030062
Gallego-Martin T, Prieto-Lloret J, Aaronson PI, Rocher A, Obeso A. Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells. Antioxidants (Basel). 2019 Mar 13;8(3). doi: 10.3390/antiox8030062. PMID: 30871199; PMCID: PMC6466535.
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Antioxidants (Basel). 2019 Mar 13;8(3). doi: 10.3390/antiox8030062.

Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells.

Antioxidants (Basel, Switzerland)

Teresa Gallego-Martin, Jesus Prieto-Lloret, Philip I Aaronson, Asuncion Rocher, Ana Obeso

Affiliations

  1. Departamento de Bioquímica y Biología Molecular y Fisiología. Facultad de Medicina. Universidad de Valladolid. Instituto de Biología y Genética Molecular-CSIC, 47005 Valladolid, Spain. [email protected].
  2. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES-ISCIII), 28029 Madrid, Spain. [email protected].
  3. Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. [email protected].
  4. Departamento de Bioquímica y Biología Molecular y Fisiología. Facultad de Medicina. Universidad de Valladolid. Instituto de Biología y Genética Molecular-CSIC, 47005 Valladolid, Spain. [email protected].
  5. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES-ISCIII), 28029 Madrid, Spain. [email protected].
  6. Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College, London SE1 1UL, UK. [email protected].
  7. Departamento de Bioquímica y Biología Molecular y Fisiología. Facultad de Medicina. Universidad de Valladolid. Instituto de Biología y Genética Molecular-CSIC, 47005 Valladolid, Spain. [email protected].
  8. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES-ISCIII), 28029 Madrid, Spain. [email protected].
  9. Departamento de Bioquímica y Biología Molecular y Fisiología. Facultad de Medicina. Universidad de Valladolid. Instituto de Biología y Genética Molecular-CSIC, 47005 Valladolid, Spain. [email protected].
  10. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES-ISCIII), 28029 Madrid, Spain. [email protected].

PMID: 30871199 PMCID: PMC6466535 DOI: 10.3390/antiox8030062

Abstract

Carotid body (CB) chemoreceptor cells sense arterial blood PO₂, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H₂S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs, although this concept remains controversial. In the present study we have used the H₂S scavenger and vitamin B

Keywords: carotid body; hydrogen sulfide; hydroxycobalamin; hypoxia; oxygen sensing

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