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Peterson MS, Joyner CJ, Cordy RJ, et al. . Open Forum Infect Dis. 2019;6(3):ofz021doi: 10.1093/ofid/ofz021.
Peterson, M. S., Joyner, C. J., Cordy, R. J., Salinas, J. L., Machiah, D., Lapp, S. A., Meyer, E. V. S., Gumber, S., & Galinski, M. R. (2019). . Open forum infectious diseases, 6(3), ofz021. https://doi.org/10.1093/ofid/ofz021
Peterson, Mariko S, et al. "." Open forum infectious diseases vol. 6,3 (2019): ofz021. doi: https://doi.org/10.1093/ofid/ofz021
Peterson MS, Joyner CJ, Cordy RJ, Salinas JL, Machiah D, Lapp SA, Meyer EVS, Gumber S, Galinski MR. . Open Forum Infect Dis. 2019 Jan 19;6(3):ofz021. doi: 10.1093/ofid/ofz021. eCollection 2019 Mar. PMID: 30937329; PMCID: PMC6436601.
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Open Forum Infect Dis. 2019 Jan 19;6(3):ofz021. doi: 10.1093/ofid/ofz021. eCollection 2019 Mar.

[No title available]

Open forum infectious diseases

Mariko S Peterson, Chester J Joyner, Regina J Cordy, Jorge L Salinas, Deepa Machiah, Stacey A Lapp, Esmeralda V S Meyer, Sanjeev Gumber, Mary R Galinski

Affiliations

  1. Emory Vaccine Center, Yerkes National Primate Research Center.
  2. Division of Infectious Diseases, Department of Medicine, School of Medicine.
  3. Division of Pathology, Yerkes National Primate Research Center.
  4. Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia.

PMID: 30937329 PMCID: PMC6436601 DOI: 10.1093/ofid/ofz021

Abstract

METHODS: We present quantitative parasitological and histopathological analyses of tissue sections from a cohort of naive, mostly splenectomized

RESULTS: The lung, liver, and kidney showed the most tissue injury, with pathological presentations similar to observations reported from autopsies. Parasite loads correlated with the degree of histopathologic changes in the lung and liver tissues. In contrast, kidney damage was not associated directly with parasite load but with the presence of hemozoin, an inflammatory parasite byproduct.

CONCLUSIONS: This analysis supports the use of the

Keywords: animal models; infectious diseases; malaria; nonhuman primates; parasite tissue load

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