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Kaderka R, Mundt RC, Li N, et al. Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites. Pract Radiat Oncol. 2019;9(4):257-265doi: 10.1016/j.prro.2019.02.010.
Kaderka, R., Mundt, R. C., Li, N., Ziemer, B., Bry, V. N., Cornell, M., & Moore, K. L. (2019). Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites. Practical radiation oncology, 9(4), 257-265. https://doi.org/10.1016/j.prro.2019.02.010
Kaderka, Robert, et al. "Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites." Practical radiation oncology vol. 9,4 (2019): 257-265. doi: https://doi.org/10.1016/j.prro.2019.02.010
Kaderka R, Mundt RC, Li N, Ziemer B, Bry VN, Cornell M, Moore KL. Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites. Pract Radiat Oncol. 2019 Jul - Aug;9(4):257-265. doi: 10.1016/j.prro.2019.02.010. Epub 2019 Mar 01. PMID: 30826481.
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Pract Radiat Oncol. 2019 Jul - Aug;9(4):257-265. doi: 10.1016/j.prro.2019.02.010. Epub 2019 Mar 01.

Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites.

Practical radiation oncology

Robert Kaderka, Robert C Mundt, Nan Li, Benjamin Ziemer, Victoria N Bry, Mariel Cornell, Kevin L Moore

Affiliations

  1. Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.
  2. Department of Radiation Oncology, University of California San Francisco, San Francisco, California.
  3. Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California. Electronic address: [email protected].

PMID: 30826481 DOI: 10.1016/j.prro.2019.02.010

Abstract

PURPOSE: Knowledge-based planning (KBP) clinical implementation necessitates significant upfront effort, even within a single disease site. The purpose of this study was to demonstrate an efficient method for clinicians to assess the noninferiority of KBP across multiple disease sites and estimate any systematic dosimetric differences after implementation. We sought to establish these endpoints in a plurality of previously treated patients (validation set) with both closed-loop (training set overlapping validation set) and open-loop (independent training set) KBP routines.

METHODS AND MATERIALS: We identified 53 prostate, 24 prostatic fossa, 54 hypofractionated lung, and 52 head and neck patients treated with volumetric modulated arc therapy in the year directly preceding our clinic's broad adoption of RapidPlan (Varian Medical Systems, Palo Alto, CA). Using the Varian Eclipse Scripting API, our program takes as input a list of patients, then performs semiautomated structure matching, fully automated RapidPlan-driven optimization, and plan comparison. All plans were normalized to the planning target volume (PTV) D

RESULTS: Statistically significant organ dose-volume histogram improvements were observed in the KBP cohort: the rectum, bladder, and penile bulb in prostate/prostatic fossa; and the larynx, esophagus, cricopharyngeus, parotid glands, and cochlea in head and neck. No OAR dose metric was statistically worse in any KBP sample. PTV ΔD

CONCLUSIONS: Our automated method showed multiple disease sites' KBP routines to be noninferior to manual planning, with statistically significant superiority in some aspects of OAR sparing. This method is applicable to any institution implementing either closed-loop or open-loop KBP autoplanning routines.

Copyright © 2019. Published by Elsevier Inc.

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