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Manickam A, Singh R, McDermott M, et al. A Fully Integrated CMOS Fluorescence Biochip for DNA and RNA Testing. IEEE J Solid-State Circuits. 2017;52(11):2857-2870doi: 10.1109/JSSC.2017.2754363.
Manickam, A., Singh, R., McDermott, M., Wood, N., Bolouki, S., Naraghi-Arani, P., Johnson, K., Kuimelis, R. G., Schoolnik, G., & Hassibi, A. (2017). A Fully Integrated CMOS Fluorescence Biochip for DNA and RNA Testing. IEEE journal of solid-state circuits, 52(11), 2857-2870. https://doi.org/10.1109/JSSC.2017.2754363
Manickam, Arun, et al. "A Fully Integrated CMOS Fluorescence Biochip for DNA and RNA Testing." IEEE journal of solid-state circuits vol. 52,11 (2017): 2857-2870. doi: https://doi.org/10.1109/JSSC.2017.2754363
Manickam A, Singh R, McDermott M, Wood N, Bolouki S, Naraghi-Arani P, Johnson K, Kuimelis RG, Schoolnik G, Hassibi A. A Fully Integrated CMOS Fluorescence Biochip for DNA and RNA Testing. IEEE J Solid-State Circuits. 2017 Nov;52(11):2857-2870. doi: 10.1109/JSSC.2017.2754363. Epub 2017 Oct 24. PMID: 30853715; PMCID: PMC6407865.
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IEEE J Solid-State Circuits. 2017 Nov;52(11):2857-2870. doi: 10.1109/JSSC.2017.2754363. Epub 2017 Oct 24.

A Fully Integrated CMOS Fluorescence Biochip for DNA and RNA Testing.

IEEE journal of solid-state circuits

Arun Manickam, Rituraj Singh, Mark McDermott, Nicholas Wood, Sara Bolouki, Pejman Naraghi-Arani, Kirsten Johnson, Robert G Kuimelis, Gary Schoolnik, Arjang Hassibi

Affiliations

  1. InSilixa, Inc., 1000 Hamlin Ct., Sunnyvale, CA 94089, United States.

PMID: 30853715 PMCID: PMC6407865 DOI: 10.1109/JSSC.2017.2754363

Abstract

Design and successful implementation of a fully-integrated CMOS fluorescence biochip for DNA/RNA testing in molecular diagnostics (MDx) is presented. The biochip includes a 32×32 array of continuous wave fluorescence detection biosensing elements. Each biosensing element is capable of having unique DNA probe sequences, wavelength-selective multi-dielectric emission filter (OD of 3.6), resistive heater for thermal cycling, and a high performance and programmable photodetector. The dimension of each biosensor is 100

Keywords: Biochip; Biosensor; Fluorescence Spectroscopy; Image Sensors; Infectious Disease; Microarray; Molecular Diagnostics; Nucleic Acid; Optical Filter; Polymerase Chain Reaction

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