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Bronkhorst AJ, Ungerer V, Holdenrieder S. The emerging role of cell-free DNA as a molecular marker for cancer management. Biomol Detect Quantif. 2019;17:100087doi: 10.1016/j.bdq.2019.100087.
Bronkhorst, A. J., Ungerer, V., & Holdenrieder, S. (2019). The emerging role of cell-free DNA as a molecular marker for cancer management. Biomolecular detection and quantification, 17100087. https://doi.org/10.1016/j.bdq.2019.100087
Bronkhorst, Abel Jacobus, et al. "The emerging role of cell-free DNA as a molecular marker for cancer management." Biomolecular detection and quantification vol. 17 (2019): 100087. doi: https://doi.org/10.1016/j.bdq.2019.100087
Bronkhorst AJ, Ungerer V, Holdenrieder S. The emerging role of cell-free DNA as a molecular marker for cancer management. Biomol Detect Quantif. 2019 Mar 18;17:100087. doi: 10.1016/j.bdq.2019.100087. eCollection 2019 Mar. PMID: 30923679; PMCID: PMC6425120.
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Biomol Detect Quantif. 2019 Mar 18;17:100087. doi: 10.1016/j.bdq.2019.100087. eCollection 2019 Mar.

The emerging role of cell-free DNA as a molecular marker for cancer management.

Biomolecular detection and quantification

Abel Jacobus Bronkhorst, Vida Ungerer, Stefan Holdenrieder

Affiliations

  1. Institute for Laboratory Medicine, German Heart Centre, Technical University Munich, Lazarettstraße. 36, D-80636, Munich, Germany.

PMID: 30923679 PMCID: PMC6425120 DOI: 10.1016/j.bdq.2019.100087

Abstract

An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and monitoring. However, harnessing the full potential of cfDNA requires (i) the optimization and standardization of preanalytical steps, (ii) refinement of current analysis strategies, and, perhaps most importantly, (iii) significant improvements in our understanding of its origin, physical properties, and dynamics in circulation. The latter knowledge is crucial for interpreting the associations between changes in the baseline characteristics of cfDNA and the clinical manifestations of cancer. In this review we explore recent advancements and highlight the current gaps in our knowledge concerning each point of contact between cfDNA analysis and the different stages of cancer management.

Keywords: Biomarker; Cancer; Cell-free DNA; Circulating tumor DNA; Liquid biopsy; Precision oncology

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