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Wadhwa R, Li L, Singh R, et al. Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin. Evid Based Complement Alternat Med. 2019;2019:9848969doi: 10.1155/2019/9848969.
Wadhwa, R., Li, L., Singh, R., Wang, J., Gao, R., Nigam, N., Forestier, S., Ando, N., & Kaul, S. C. (2019). Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin. Evidence-based complementary and alternative medicine : eCAM, 20199848969. https://doi.org/10.1155/2019/9848969
Wadhwa, Renu, et al. "Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin." Evidence-based complementary and alternative medicine : eCAM vol. 2019 (2019): 9848969. doi: https://doi.org/10.1155/2019/9848969
Wadhwa R, Li L, Singh R, Wang J, Gao R, Nigam N, Forestier S, Ando N, Kaul SC. Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin. Evid Based Complement Alternat Med. 2019 Apr 14;2019:9848969. doi: 10.1155/2019/9848969. eCollection 2019. PMID: 31097976; PMCID: PMC6487102.
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Evid Based Complement Alternat Med. 2019 Apr 14;2019:9848969. doi: 10.1155/2019/9848969. eCollection 2019.

Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin.

Evidence-based complementary and alternative medicine : eCAM

Renu Wadhwa, Ling Li, Rumani Singh, Jia Wang, Ran Gao, Nupur Nigam, Sandra Forestier, Nobuhiro Ando, Sunil C Kaul

Affiliations

  1. DAILAB, DBT-AIST International Center for Translational and Environmental Research (DAICENTER), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba 305-8565, Japan.
  2. KK Chanel Research and Technology Development Laboratory, 1-1-5, Yamate, Funabashi-Chiba 273-0045, Japan.

PMID: 31097976 PMCID: PMC6487102 DOI: 10.1155/2019/9848969

Abstract

Skin color/pigmentation is regulated through melanogenesis process in specialized melanin-producing cells, melanocytes, involving multiple signaling pathways. It is highly influenced by intrinsic and extrinsic factors such as oxidative, ultraviolet radiations and other environmental stress conditions. Besides determining the color, it governs response and tolerance of skin to a variety of environmental stresses and pathological conditions including photodamage, hyperpigmentation, and skin cancer. Depigmenting reagents have been deemed useful not only for cosmetics but also for pigmentation-related pathologies. In the present study, we attempted modulation of 1-oleoyl-2-acetyl-glycerol- (OAG-) induced melanogenesis in human melanoma and primary melanocytes. In both cell types, OAG-induced melanogenesis was associated with increase in enhanced expression of melanin, tyrosinase, as well as stress chaperones (mortalin and HSP60) and Reactive Oxygen Species (ROS). Treatment with TXC (trans-4-(Aminomethyl) cyclohexanecarboxylic acid hexadecyl ester hydrochloride) and 5/40 natural compounds resulted in their reduction. The data proposed an important role of mortalin and oxidative stress in skin pigmentation and the use of TXC and natural extracts for modulation of pigmentation pathways in normal and pathological conditions.

References

  1. J Biol Chem. 2002 Oct 4;277(40):37765-70 - PubMed
  2. J Dermatol. 2003 Sep;30(9):665-72 - PubMed
  3. Eur J Cancer. 2004 Jun;40(9):1423-30 - PubMed
  4. Chem Biol. 2004 Sep;11(9):1251-9 - PubMed
  5. Cell Mol Life Sci. 2004 Nov;61(22):2878-85 - PubMed
  6. Ned Tijdschr Geneeskd. 2004 Nov 13;148(46):2267-72 - PubMed
  7. Chem Biol. 2005 Apr;12(4):412-3 - PubMed
  8. Chem Biol. 2005 Apr;12(4):477-84 - PubMed
  9. Cell Stress Chaperones. 2006 Summer;11(2):116-28 - PubMed
  10. Mol Cell Proteomics. 2007 May;6(5):845-59 - PubMed
  11. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89 - PubMed
  12. J Am Acad Dermatol. 2008 May;58(5 Suppl 2):S139-48 - PubMed
  13. Pigment Cell Melanoma Res. 2008 Apr;21(2):200-5 - PubMed
  14. Mol Cell Biol. 2008 Jul;28(13):4424-33 - PubMed
  15. Am J Chin Med. 2008;36(2):245-63 - PubMed
  16. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 Sep;37(5):524-30 - PubMed
  17. Br J Dermatol. 2010 Jan;162(1):22-8 - PubMed
  18. Pigment Cell Melanoma Res. 2010 Apr;23(2):171-86 - PubMed
  19. Exp Dermatol. 2010 Aug;19(8):e340-2 - PubMed
  20. Exp Dermatol. 2010 Jul 1;19(7):617-27 - PubMed
  21. Int J Pharm. 2010 May 31;391(1-2):115-24 - PubMed
  22. Int J Cosmet Sci. 2011 Oct;33(5):398-407 - PubMed
  23. Mov Disord. 2011 Aug 1;26(9):1639-47 - PubMed
  24. Biochem Pharmacol. 2012 Apr 1;83(7):909-22 - PubMed
  25. J R Coll Physicians Edinb. 2012 Mar;42(1):58-63 - PubMed
  26. PLoS One. 2012;7(9):e45183 - PubMed
  27. J Cell Physiol. 1990 Feb;142(2):334-41 - PubMed
  28. Oncol Rep. 2013 Apr;29(4):1600-8 - PubMed
  29. Int J Biochem Cell Biol. 2013 Jul;45(7):1217-22 - PubMed
  30. Acta Neurobiol Exp (Wars). 2013;73(2):199-224 - PubMed
  31. PLoS One. 2013 Dec 30;8(12):e83714 - PubMed
  32. Curr Biol. 2014 Feb 17;24(4):393-403 - PubMed
  33. J Invest Dermatol. 2014 Jun;134(6):1512-1518 - PubMed
  34. J Am Acad Dermatol. 2014 Sep;71(3):586 - PubMed
  35. Brain Res. 2015 Apr 16;1604:52-61 - PubMed
  36. J Dermatol Sci. 2015 Apr;78(1):67-75 - PubMed
  37. Mol Biol Cell. 2015 Jun 15;26(12):2156-67 - PubMed
  38. Redox Biol. 2016 Aug;8:79-90 - PubMed
  39. Cell Stress Chaperones. 2016 Jul;21(4):631-44 - PubMed
  40. Oxid Med Cell Longev. 2016;2016:3401570 - PubMed
  41. Sci Rep. 2017 Oct 11;7(1):12957 - PubMed
  42. Ultrastruct Pathol. 2018 Mar-Apr;42(2):170-180 - PubMed
  43. J Dermatol Sci. 1995 May;9(3):157-64 - PubMed
  44. Oncogene. 1998 Oct 1;17(13):1653-62 - PubMed

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