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Guimaraes AO, Gutierrez J, Maskarinec SA, et al. Prognostic Power of Pathogen Cell-Free DNA in . Open Forum Infect Dis. 2019;6(4):ofz126doi: 10.1093/ofid/ofz126.
Guimaraes, A. O., Gutierrez, J., Maskarinec, S. A., Cao, Y., Hong, K., Ruffin, F., Carrasco-Triguero, M., Peck, M. C., Fowler, V. G., Baruch, A., & Rosenberger, C. M. (2019). Prognostic Power of Pathogen Cell-Free DNA in . Open forum infectious diseases, 6(4), ofz126. https://doi.org/10.1093/ofid/ofz126
Guimaraes, Alessander O, et al. "Prognostic Power of Pathogen Cell-Free DNA in ." Open forum infectious diseases vol. 6,4 (2019): ofz126. doi: https://doi.org/10.1093/ofid/ofz126
Guimaraes AO, Gutierrez J, Maskarinec SA, Cao Y, Hong K, Ruffin F, Carrasco-Triguero M, Peck MC, Fowler VG, Baruch A, Rosenberger CM. Prognostic Power of Pathogen Cell-Free DNA in . Open Forum Infect Dis. 2019 Mar 15;6(4):ofz126. doi: 10.1093/ofid/ofz126. eCollection 2019 Apr. PMID: 31041341; PMCID: PMC6483138.
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Open Forum Infect Dis. 2019 Mar 15;6(4):ofz126. doi: 10.1093/ofid/ofz126. eCollection 2019 Apr.

Prognostic Power of Pathogen Cell-Free DNA in .

Open forum infectious diseases

Alessander O Guimaraes, Johnny Gutierrez, Stacey A Maskarinec, Yi Cao, Kyu Hong, Felicia Ruffin, Montserrat Carrasco-Triguero, Melicent C Peck, Vance G Fowler, Amos Baruch, Carrie M Rosenberger

Affiliations

  1. Biomarker Discovery, Genentech, Inc., South San Francisco, California.
  2. Biomarker Development, Genentech, Inc., South San Francisco, California.
  3. Division of Infectious Diseases, Duke University Division of Infectious Diseases, Durham, North Carolina.
  4. Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, California.
  5. Bioanalytical Sciences, Genentech, Inc., South San Francisco, California.
  6. Clinical Sciences, Genentech, Inc., South San Francisco, California.

PMID: 31041341 PMCID: PMC6483138 DOI: 10.1093/ofid/ofz126

Abstract

RESULTS: High levels of

CONCLUSIONS: Measurements of bacterial load by PCR are a clinically feasible candidate biomarker for stratifying patients at higher risk for complications and poor outcomes. Their diagnostic and prognostic value for identifying foci of infection and influencing treatment remain to be evaluated in additional cohorts.

Keywords: Staphylococcus aureus; bacteremia; cell-free DNA; prognostic biomarkers

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