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Zimmermann A, Kainz K, Hofer SJ, et al. Targeting GATA transcription factors - a novel strategy for anti-aging interventions?. Microb Cell. 2019;6(5):212-216doi: 10.15698/mic2019.05.676.
Zimmermann, A., Kainz, K., Hofer, S. J., Bauer, M. A., Schroeder, S., Dengjel, J., Pietrocola, F., Kepp, O., Ruckenstuhl, C., Eisenberg, T., Sigrist, S. J., Madeo, F., Kroemer, G., & Carmona-Gutierrez, D. (2019). Targeting GATA transcription factors - a novel strategy for anti-aging interventions?. Microbial cell (Graz, Austria), 6(5), 212-216. https://doi.org/10.15698/mic2019.05.676
Zimmermann, Andreas, et al. "Targeting GATA transcription factors - a novel strategy for anti-aging interventions?." Microbial cell (Graz, Austria) vol. 6,5 (2019): 212-216. doi: https://doi.org/10.15698/mic2019.05.676
Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Kroemer G, Carmona-Gutierrez D. Targeting GATA transcription factors - a novel strategy for anti-aging interventions?. Microb Cell. 2019 May 06;6(5):212-216. doi: 10.15698/mic2019.05.676. PMID: 31114793; PMCID: PMC6506692.
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Microb Cell. 2019 May 06;6(5):212-216. doi: 10.15698/mic2019.05.676.

Targeting GATA transcription factors - a novel strategy for anti-aging interventions?.

Microbial cell (Graz, Austria)

Andreas Zimmermann, Katharina Kainz, Sebastian J Hofer, Maria A Bauer, Sabrina Schroeder, Jörn Dengjel, Federico Pietrocola, Oliver Kepp, Christoph Ruckenstuhl, Tobias Eisenberg, Stephan J Sigrist, Frank Madeo, Guido Kroemer, Didac Carmona-Gutierrez

Affiliations

  1. Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  2. Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  3. BioTechMed Graz, Graz, Austria.
  4. Department of Biology, Université de Fribourg, Switzerland.
  5. Institute for Research in Biomedicine; Barcelona, Spain.
  6. Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France.
  7. Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
  8. Université de Paris, Paris, France.
  9. Sorbonne Université Paris, France.
  10. BioHealth Graz, Graz, Austria.
  11. Central Lab Gracia, NAWI Graz, University of Graz, Graz, Austria.
  12. Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.
  13. Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.
  14. Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China.
  15. Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

PMID: 31114793 PMCID: PMC6506692 DOI: 10.15698/mic2019.05.676

Abstract

GATA transcription factors (TFs) are a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we have identified a natural compound, 4,4' dimethoxychalcone (DMC) that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged lifespan by DMC treatment depends on autophagy, a protective cellular self-cleaning mechanism. In yeast, DMC reduces the activity of the GATA TF Gln3 and, at the same time, deletion of GLN3 increases autophagy levels during cellular aging per se. Here, we examine current data on the involvement of GATA TFs in the regulation of both autophagy and lifespan in different organisms and explore, if GATA TFs are suitable targets for anti-aging interventions.

Conflict of interest statement

Conflict of interest: O.K., G.K., D.C-G. and F.M. are the scientific co-founders of Samsara Therapeutics.

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