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Showing 1 to 12 of 32 entries
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Sexually transmitted infections: old foes on the rise.

Microbial cell (Graz, Austria)

Carmona-Gutierrez D, Kainz K, Madeo F.
PMID: 28357374
Microb Cell. 2016 Sep 05;3(9):361-362. doi: 10.15698/mic2016.09.522.

Sexually transmitted infections (STIs) are commonly spread via sexual contact. It is estimated that one million STIs are acquired every day worldwide. Besides their impact on sexual, reproductive and neonatal health, they can cause disastrous and life-threatening complications if...

Cell cycle control of cell death in yeast.

Cell cycle (Georgetown, Tex.)

Carmona-Gutierrez D, Jungwirth H, Eisenberg T, Madeo F.
PMID: 20980804
Cell Cycle. 2010 Oct;9(20):4046. doi: 10.4161/cc.9.20.13523. Epub 2010 Oct 15.

No abstract available.

Microbial wars: Competition in ecological niches and within the microbiome.

Microbial cell (Graz, Austria)

Bauer MA, Kainz K, Carmona-Gutierrez D, Madeo F.
PMID: 29796386
Microb Cell. 2018 May 07;5(5):215-219. doi: 10.15698/mic2018.05.628.

Many microbial communities live in highly competitive surroundings, in which the fight for resources determines their survival and genetic persistence. Humans live in a close relationship with microbial communities, which includes the health- and disease-determining interactions with our microbiome....

Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin.

Microbial cell (Graz, Austria)

Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F.
PMID: 29234670
Microb Cell. 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603.

Hereditary spastic paraplegias, a group of neurodegenerative disorders, can be caused by loss-of-function mutations in the protein spartin. However, the physiological role of spartin remains largely elusive. Here we show that heterologous expression of human or

Spermidine supplementation in rare translation-associated disorders.

Cell stress

Zimmermann A, Carmona-Gutierrez D, Madeo F.
PMID: 33688620
Cell Stress. 2021 Mar 08;5(3):29-32. doi: 10.15698/cst2021.03.243.

The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced...

Targeting GATA transcription factors - a novel strategy for anti-aging interventions?.

Microbial cell (Graz, Austria)

Zimmermann A, Kainz K, Hofer SJ, Bauer MA, Schroeder S, Dengjel J, Pietrocola F, Kepp O, Ruckenstuhl C, Eisenberg T, Sigrist SJ, Madeo F, Kroemer G, Carmona-Gutierrez D.
PMID: 31114793
Microb Cell. 2019 May 06;6(5):212-216. doi: 10.15698/mic2019.05.676.

GATA transcription factors (TFs) are a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we have identified a natural...

Dietary spermidine improves cognitive function.

Cell reports

Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F.
PMID: 33852843
Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985.

Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promoting polyamine. Here, we show that...

Studying Huntington's Disease in Yeast: From Mechanisms to Pharmacological Approaches.

Frontiers in molecular neuroscience

Hofer S, Kainz K, Zimmermann A, Bauer MA, Pendl T, Poglitsch M, Madeo F, Carmona-Gutierrez D.
PMID: 30233317
Front Mol Neurosci. 2018 Sep 04;11:318. doi: 10.3389/fnmol.2018.00318. eCollection 2018.

Huntington's disease (HD) is a neurodegenerative disorder that leads to progressive neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD remains incurable, and available drugs are effective only for symptomatic management. HD is caused by...

Cell stress

Zimmermann A, Ruckenstuhl C, Kainz K, Hofer S, Madeo F, Carmona-Gutierrez D, Kroemer G.
PMID: 31225431
Cell Stress. 2017 Oct 01;1(1):1-3. doi: 10.15698/cst2017.10.101.

No abstract available.

The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.

Frontiers in molecular neuroscience

Aufschnaiter A, Habernig L, Kohler V, Diessl J, Carmona-Gutierrez D, Eisenberg T, Keller W, Büttner S.
PMID: 28713240
Front Mol Neurosci. 2017 Jun 30;10:207. doi: 10.3389/fnmol.2017.00207. eCollection 2017.

The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in...

The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans.

Frontiers in microbiology

Aerts AM, Bammens L, Govaert G, Carmona-Gutierrez D, Madeo F, Cammue BP, Thevissen K.
PMID: 21993350
Front Microbiol. 2011 Mar 16;2:47. doi: 10.3389/fmicb.2011.00047. eCollection 2011.

Plant defensins are active against plant and human pathogenic fungi (such as Candida albicans) and baker's yeast. However, they are non-toxic to human cells, providing a possible source for treatment of fungal infections. In this study, we characterized the...

One cell, one love: a journal for microbial research.

Microbial cell (Graz, Austria)

Carmona-Gutierrez D, Kroemer G, Madeo F.
PMID: 28357205
Microb Cell. 2014 Jan 06;1(1):1-5. doi: 10.15698/mic2014.01.118.

No abstract available.

Showing 1 to 12 of 32 entries