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Silberstein M, Nunn AK, Drummond PD, et al. A Human Sensory Pathway Connecting the Foot to Ipsilateral Face That Partially Bypasses the Spinal Cord. Front Neurosci. 2019;13:519doi: 10.3389/fnins.2019.00519.
Silberstein, M., Nunn, A. K., Drummond, P. D., Wan, D. W. L., Alexander, J., Millard, M., & Galea, M. P. (2019). A Human Sensory Pathway Connecting the Foot to Ipsilateral Face That Partially Bypasses the Spinal Cord. Frontiers in neuroscience, 13519. https://doi.org/10.3389/fnins.2019.00519
Silberstein, Morry, et al. "A Human Sensory Pathway Connecting the Foot to Ipsilateral Face That Partially Bypasses the Spinal Cord." Frontiers in neuroscience vol. 13 (2019): 519. doi: https://doi.org/10.3389/fnins.2019.00519
Silberstein M, Nunn AK, Drummond PD, Wan DWL, Alexander J, Millard M, Galea MP. A Human Sensory Pathway Connecting the Foot to Ipsilateral Face That Partially Bypasses the Spinal Cord. Front Neurosci. 2019 May 22;13:519. doi: 10.3389/fnins.2019.00519. eCollection 2019. PMID: 31191224; PMCID: PMC6539214.
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Front Neurosci. 2019 May 22;13:519. doi: 10.3389/fnins.2019.00519. eCollection 2019.

A Human Sensory Pathway Connecting the Foot to Ipsilateral Face That Partially Bypasses the Spinal Cord.

Frontiers in neuroscience

Morry Silberstein, Andrew K Nunn, Peter D Drummond, Dawn Wong Lit Wan, Janette Alexander, Melinda Millard, Mary P Galea

Affiliations

  1. School of Molecular and Life Sciences, Curtin University, Perth, WA, Australia.
  2. Victorian Spinal Cord Service, Austin Health, Melbourne, VIC, Australia.
  3. School of Psychology, Murdoch University, Murdoch, WA, Australia.
  4. School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
  5. Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.

PMID: 31191224 PMCID: PMC6539214 DOI: 10.3389/fnins.2019.00519

Abstract

Human sensory transmission from limbs to brain crosses and ascends through the spinal cord. Yet, descriptions exist of ipsilateral sensory transmission as well as transmission after spinal cord transection. To elucidate a novel ipsilateral cutaneous pathway, we measured facial perfusion following painfully-cold water foot immersion in 10 complete spinal cord-injured patients, 10 healthy humans before and after lower thigh capsaicin C-fiber cutaneous conduction blockade, and 10 warm-immersed healthy participants. As in healthy volunteers, ipsilateral facial perfusion in spinal cord injured patients increased significantly. Capsaicin resulted in contralateral increase in perfusion, but only following cold immersion and not in 2 spinal cord-injured patients who underwent capsaicin administration. Supported by skin biopsy results from a healthy participant, we speculate that the pathway involves peripheral C-fiber cross-talk, partially bypassing the cord. This might also explain referred itch and jogger's migraine and it is possible that it may be amenable to training spinal-injured patients to recognize lower limb sensory stimuli.

Keywords: C-fiber; afferent; capsaicin; neuroanantomy; pain

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