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Johnson EL, Reynolds DL, Wright DS, et al. Biological sample preparation and data reduction concepts in pharmaceutical analysis. J Chromatogr Sci. 1988;26(8):372-9doi: 10.1093/chromsci/26.8.372.
Johnson, E. L., Reynolds, D. L., Wright, D. S., & Pachla, L. A. (1988). Biological sample preparation and data reduction concepts in pharmaceutical analysis. Journal of chromatographic science, 26(8), 372-9. https://doi.org/10.1093/chromsci/26.8.372
Johnson, E L, et al. "Biological sample preparation and data reduction concepts in pharmaceutical analysis." Journal of chromatographic science vol. 26,8 (1988): 372-9. doi: https://doi.org/10.1093/chromsci/26.8.372
Johnson EL, Reynolds DL, Wright DS, Pachla LA. Biological sample preparation and data reduction concepts in pharmaceutical analysis. J Chromatogr Sci. 1988 Aug;26(8):372-9. doi: 10.1093/chromsci/26.8.372. PMID: 3063720.
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J Chromatogr Sci. 1988 Aug;26(8):372-9. doi: 10.1093/chromsci/26.8.372.

Biological sample preparation and data reduction concepts in pharmaceutical analysis.

Journal of chromatographic science

E L Johnson, D L Reynolds, D S Wright, L A Pachla

Affiliations

  1. Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.

PMID: 3063720 DOI: 10.1093/chromsci/26.8.372

Abstract

This paper describes strategies to rapidly develop sensitive and selective preparations using manual and robotic liquid-solid isolation (LSI) methods. LSI procedures offer selective isolation of drug or metabolites from complex matrices and are applicable to many pharmaceutical compounds. The beneficial effect of weighted linear regression is described, and several data reduction techniques are contrasted.

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