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Li J, Bai L, Wei F, et al. Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review. Front Pharmacol. 2019;10:661doi: 10.3389/fphar.2019.00661.
Li, J., Bai, L., Wei, F., Zhao, J., Wang, D., Xiao, Y., Yan, W., & Wei, J. (2019). Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review. Frontiers in pharmacology, 10661. https://doi.org/10.3389/fphar.2019.00661
Li, Jun, et al. "Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review." Frontiers in pharmacology vol. 10 (2019): 661. doi: https://doi.org/10.3389/fphar.2019.00661
Li J, Bai L, Wei F, Zhao J, Wang D, Xiao Y, Yan W, Wei J. Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review. Front Pharmacol. 2019 Jun 14;10:661. doi: 10.3389/fphar.2019.00661. eCollection 2019. PMID: 31258478; PMCID: PMC6587894.
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Front Pharmacol. 2019 Jun 14;10:661. doi: 10.3389/fphar.2019.00661. eCollection 2019.

Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review.

Frontiers in pharmacology

Jun Li, Litao Bai, Fan Wei, Jing Zhao, Danwei Wang, Yao Xiao, Weitian Yan, Junping Wei

Affiliations

  1. Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
  2. Graduate School, Beijing University of Chinese Medicine, Beijing, China.

PMID: 31258478 PMCID: PMC6587894 DOI: 10.3389/fphar.2019.00661

Abstract

Insulin resistance is a condition in which insulin sensitivity is reduced and the insulin signaling pathway is impaired. Although often expressed as an increase in insulin concentration, the disease is characterized by a decrease in insulin action. This increased workload of the pancreas and the consequent decompensation are not only the main mechanisms for the development of type 2 diabetes (T2D), but also exacerbate the damage of metabolic diseases, including obesity, nonalcoholic fatty liver disease, polycystic ovary syndrome, metabolic syndrome, and others. Many clinical trials have suggested the potential role of herbs in the treatment of insulin resistance, although most of the clinical trials included in this review have certain flaws and bias risks in their methodological design, including the generation of randomization, the concealment of allocation, blinding, and inadequate reporting of sample size estimates. These studies involve not only the single-flavored herbs, but also herbal formulas, extracts, and active ingredients. Numerous of

Keywords: herbal medicine; insulin resistance; mechanism; pathway; signal transduction

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