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Zhou F, Huang L, Qu SL, et al. The emerging roles of extracellular vesicles in diabetes and diabetic complications. Clin Chim Acta. 2019;497:130-136doi: 10.1016/j.cca.2019.07.032.
Zhou, F., Huang, L., Qu, S. L., Chao, R., Yang, C., Jiang, Z. S., & Zhang, C. (2019). The emerging roles of extracellular vesicles in diabetes and diabetic complications. Clinica chimica acta; international journal of clinical chemistry, 497130-136. https://doi.org/10.1016/j.cca.2019.07.032
Zhou, Fan, et al. "The emerging roles of extracellular vesicles in diabetes and diabetic complications." Clinica chimica acta; international journal of clinical chemistry vol. 497 (2019): 130-136. doi: https://doi.org/10.1016/j.cca.2019.07.032
Zhou F, Huang L, Qu SL, Chao R, Yang C, Jiang ZS, Zhang C. The emerging roles of extracellular vesicles in diabetes and diabetic complications. Clin Chim Acta. 2019 Oct;497:130-136. doi: 10.1016/j.cca.2019.07.032. Epub 2019 Jul 27. PMID: 31361990.
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Clin Chim Acta. 2019 Oct;497:130-136. doi: 10.1016/j.cca.2019.07.032. Epub 2019 Jul 27.

The emerging roles of extracellular vesicles in diabetes and diabetic complications.

Clinica chimica acta; international journal of clinical chemistry

Fan Zhou, Liang Huang, Shun-Lin Qu, Ru Chao, Chen Yang, Zhi-Sheng Jiang, Chi Zhang

Affiliations

  1. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, PR China.
  2. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, PR China; Department of Operative Surgery, School of Medicine, University of South China, Hengyang, Hunan 421002, PR China.
  3. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: [email protected].

PMID: 31361990 DOI: 10.1016/j.cca.2019.07.032

Abstract

Diabetes and diabetic vascular complications are now the leading cause of death in the world. The effects of traditional medical treatment are usually limited and accompanied by many side effects, such as hypoglycemia, obesity, liver and kidney damage, and gastrointestinal adverse reactions. Thus, it is urgent to explore some new strategies for the treatment of patients with diabetes. Recently, extracellular vesicles have received increased attention because of their emerging roles of cell-to-cell communication under physiological and pathological conditions. In addition, because of their abundant existence in almost all body fluids, as well as their plentiful cargos of bioactive proteins and miRNAs they carry, extracellular vesicles have a strong potential for therapeutic and diagnostic applications in many metabolic diseases, such as obesity and insulin resistance. Here, with the aim of providing the basis for the development of new treatments for diabetes, we review current understanding of extracellular vesicles and the critical roles it has played in the onset and progression of diabetes and diabetic complications.

Copyright © 2019 Elsevier B.V. All rights reserved.

Keywords: Diabetes; Diabetic complications; Extracellular vesicles; miRNAs

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