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Fu S, Meng Y, Zhang W, et al. Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats. Front Physiol. 2019;10:872doi: 10.3389/fphys.2019.00872.
Fu, S., Meng, Y., Zhang, W., Wang, J., He, Y., Huang, L., Chen, H., Kuang, J., & Du, H. (2019). Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats. Frontiers in physiology, 10872. https://doi.org/10.3389/fphys.2019.00872
Fu, Shuying, et al. "Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats." Frontiers in physiology vol. 10 (2019): 872. doi: https://doi.org/10.3389/fphys.2019.00872
Fu S, Meng Y, Zhang W, Wang J, He Y, Huang L, Chen H, Kuang J, Du H. Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats. Front Physiol. 2019 Jul 09;10:872. doi: 10.3389/fphys.2019.00872. eCollection 2019. PMID: 31338039; PMCID: PMC6629899.
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Front Physiol. 2019 Jul 09;10:872. doi: 10.3389/fphys.2019.00872. eCollection 2019.

Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats.

Frontiers in physiology

Shuying Fu, Yuhuan Meng, Wenlu Zhang, Jiajian Wang, Yuting He, Lizhen Huang, Hongmei Chen, Jian Kuang, Hongli Du

Affiliations

  1. School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
  2. Department of Endocrinology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, China.

PMID: 31338039 PMCID: PMC6629899 DOI: 10.3389/fphys.2019.00872

Abstract

Physical activity exerts positive effects on glycemic control in type 2 diabetes (T2D), which is mediated in part by extensive metabolic and molecular remodeling of skeletal muscle in response to exercise, while many regulators of skeletal muscle remain unclear. In the present study, we investigated the effects of acute exercise on skeletal muscle transcriptomic responses in the Goto-Kakizaki (GK) rats which can spontaneously develop T2D. The transcriptomes of skeletal muscle from both 8-week-old GK and Wistar rats that underwent a single exercise session (60 min running using an animal treadmill at 15 m/min) or remained sedentary were analyzed by next-generation RNA sequencing. We identified 819 differentially expressed genes in the sedentary GK rats compared with those of the sedentary Wistar rats. After a single bout of running, we found 291 and 598 genes that were differentially expressed in the exercise GK and exercise Wistar rats when compared with the corresponding sedentary rats. By integrating our data and previous studies including RNA or protein expression patterns and transgenic experiments, the downregulated expression of

Keywords: Goto-Kakizaki (GK) rat; RNA-Seq; acute exercise; skeletal muscle; type 2 diabetes (T2D)

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