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Fidele NB, Bing L, Sun Y, et al. Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncol Lett. 2019;18(1):733-741doi: 10.3892/ol.2019.10367.
Fidele, N. B., Bing, L., Sun, Y., Wu, T., Zheng, Y., & Zhao, Y. (2019). Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncology letters, 18(1), 733-741. https://doi.org/10.3892/ol.2019.10367
Fidele, Nyimi Bushabu, et al. "Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases." Oncology letters vol. 18,1 (2019): 733-741. doi: https://doi.org/10.3892/ol.2019.10367
Fidele NB, Bing L, Sun Y, Wu T, Zheng Y, Zhao Y. Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases. Oncol Lett. 2019 Jul;18(1):733-741. doi: 10.3892/ol.2019.10367. Epub 2019 May 17. PMID: 31289548; PMCID: PMC6540166.
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Oncol Lett. 2019 Jul;18(1):733-741. doi: 10.3892/ol.2019.10367. Epub 2019 May 17.

Management of mandibular odontogenic keratocyst through radical resection: Report of 35 cases.

Oncology letters

Nyimi Bushabu Fidele, Liu Bing, Yanfang Sun, Tianfu Wu, Yueyu Zheng, Yifang Zhao

Affiliations

  1. Department of Oral Maxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China.
  2. The State Key Laboratory Breeding Base of Basic Science of Stomatology, and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China.

PMID: 31289548 PMCID: PMC6540166 DOI: 10.3892/ol.2019.10367

Abstract

The present study reported the clinical outcomes of 35 patients with mandibular odontogenic keratocysts (OKCs) following treatment by radical resection and immediate defect reconstruction. Amongst 565 patients with OKCs that were treated between April 2003 and May 2015, 35 patients underwent segmental or marginal mandibulectomy. The use of radical resection was based on clinical and/or radiographic evidence of size, cortical perforation and subsequent soft tissue involvement, and on the history of previous recurrence of the same lesion. Recurrence, justifications of the main major factor for resection, and functional and cosmetic results of the patients following mandibular reconstruction were systematically evaluated. There were 26 OKCs in the mandibular molar-ramus region, eight in the mandibular anterior-premolar region and one in the mandibular molar-ramus and anterior-molar regions. Among the 35 patients, 20 had primary OKCs and 15 had recurrent OKCs. A total of 31 patients underwent segmental mandibulectomy, of which 28 were immediately reconstructed with a vascularized flap, whereas four patients underwent marginal mandibulectomy. The functional and cosmetic outcomes of patients were evaluated as satisfactory. The length of the follow-up period ranged from 2 to 17 years following operation (average, 5.82 years). Recurrence was identified in one patient who had been treated with marginal mandibulectomy. In conclusion, the findings from the present study suggested that radical resection may be recommended for patients with OKCs and locally aggressive features. Immediate mandibular reconstruction with a vascularized flap may be a crucial part of this aggressive treatment method that may reduce OKCs-associated morbidity.

Keywords: bone graft; mandibular reconstruction; odontogenic keratocyst; radical resection; recurrence

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