Display options
Cite
James NL, Milijasevic Z, Ujhazy A, et al. The common carotid artery provides significant pressure wave dampening in the young adult sheep. Int J Cardiol Heart Vasc. 2019;23:100343doi: 10.1016/j.ijcha.2019.03.003.
James, N. L., Milijasevic, Z., Ujhazy, A., Edwards, G., Jermyn, K., Mynard, J. P., & Celermajer, D. S. (2019). The common carotid artery provides significant pressure wave dampening in the young adult sheep. International journal of cardiology. Heart & vasculature, 23100343. https://doi.org/10.1016/j.ijcha.2019.03.003
James, Natalie L, et al. "The common carotid artery provides significant pressure wave dampening in the young adult sheep." International journal of cardiology. Heart & vasculature vol. 23 (2019): 100343. doi: https://doi.org/10.1016/j.ijcha.2019.03.003
James NL, Milijasevic Z, Ujhazy A, Edwards G, Jermyn K, Mynard JP, Celermajer DS. The common carotid artery provides significant pressure wave dampening in the young adult sheep. Int J Cardiol Heart Vasc. 2019 Mar 22;23:100343. doi: 10.1016/j.ijcha.2019.03.003. eCollection 2019 Jun. PMID: 31321284; PMCID: PMC6612755.
Copy Download .nbib Format: NLM
Share it on

Int J Cardiol Heart Vasc. 2019 Mar 22;23:100343. doi: 10.1016/j.ijcha.2019.03.003. eCollection 2019 Jun.

The common carotid artery provides significant pressure wave dampening in the young adult sheep.

International journal of cardiology. Heart & vasculature

Natalie L James, Zoran Milijasevic, Anthony Ujhazy, Glenn Edwards, Kieri Jermyn, Jonathan P Mynard, David S Celermajer

Affiliations

  1. The Brain Protection Company, Sydney, New South Wales, Australia.
  2. School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
  3. Heart Research, Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
  4. Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
  5. Department of Biomedical Engineering, University of Melbourne, Parkville, Victoria, Australia.
  6. Clinical Research Group, The Heart Research Institute, Sydney, New South Wales, Australia.

PMID: 31321284 PMCID: PMC6612755 DOI: 10.1016/j.ijcha.2019.03.003

Abstract

BACKGROUND: It has been established that the central elastic arteries of the mammalian circulation dampen the high pulse pressure emanating from the left ventricle, so that the pulsations in distal arterioles, such as in the cerebral circulation, are of lower amplitude than more centrally. However, the contribution of the common carotid artery (CCA) to protection of the cerebral microvasculature from high pulse pressure is not known, specifically to what extent viscoelastic energy dissipation in the arterial wall might contribute to the shock absorbing function of the large conduit arteries.

METHODS: Young adult sheep (n = 6) were anaesthetised and their CCAs (n = 7) exposed. Pressure catheters were inserted 10-15 cm apart, proximally and distally in the CCA; a flow probe was placed proximally on the vessel.

RESULTS: The median dp/dt

CONCLUSIONS: The native CCA in the young adult sheep is an effective "pressure dampener" in the arterial circulation, reducing both pressure slope and pulse pressure, most likely via viscous dampening in the arterial wall.

Keywords: Common carotid artery; Dampening; Pulse pressure wave

References

  1. Neurobiol Aging. 2006 Dec;27(12):1786-96 - PubMed
  2. J Biomech. 2007;40(10):2130-8 - PubMed
  3. Med Biol Eng Comput. 2009 Feb;47(2):131-41 - PubMed
  4. J Biomech. 2008 Dec 5;41(16):3314-21 - PubMed
  5. Brain. 2011 Nov;134(Pt 11):3398-407 - PubMed
  6. J Alzheimers Dis. 2015;44(2):355-73 - PubMed
  7. Hypertension. 2015 Jan;65(1):218-24 - PubMed
  8. J Neurointerv Surg. 2016 May;8(5):536-40 - PubMed
  9. Eur Heart J. 2018 Sep 1;39(33):3119-3125 - PubMed
  10. Am J Physiol. 1986 Feb;250(2 Pt 2):H181-8 - PubMed

Publication Types