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Zhao W, Jia L, Zhang M, et al. The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer. Am J Cancer Res. 2019;9(8):1846-1856
Zhao, W., Jia, L., Zhang, M., Huang, X., Qian, P., Tang, Q., Zhu, J., & Feng, Z. (2019). The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer. American journal of cancer research, 9(8), 1846-1856.
Zhao, Wei, et al. "The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer." American journal of cancer research vol. 9,8 (2019): 1846-1856.
Zhao W, Jia L, Zhang M, Huang X, Qian P, Tang Q, Zhu J, Feng Z. The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer. Am J Cancer Res. 2019 Aug 01;9(8):1846-1856. eCollection 2019. PMID: 31497363; PMCID: PMC6726977.
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Am J Cancer Res. 2019 Aug 01;9(8):1846-1856. eCollection 2019.

The killing effect of novel bi-specific Trop2/PD-L1 CAR-T cell targeted gastric cancer.

American journal of cancer research

Wei Zhao, Lizhou Jia, Mingjiong Zhang, Xiaochen Huang, Peng Qian, Qi Tang, Jin Zhu, Zhenqing Feng

Affiliations

  1. Department of Pathology, Nanjing First Hospital, Nanjing Medical University Nanjing 210006, China.
  2. Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University Nanjing 211166, China.
  3. Department of Pathology, Nanjing Medical University Nanjing 211166, China.
  4. Central Laboratory, Bayannur Hospital Inner Mongolia 015000, China.
  5. Sinobioway Cell Therapy Co., Ltd. Hefei 238000, China.
  6. Huadong Medical Institute of Biotechniques Nanjing 210000, China.
  7. Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University Nanjing 211166, China.

PMID: 31497363 PMCID: PMC6726977

Abstract

Due to their high heterogeneity and complex tumor microenvironment, the treatment of solid tumors by CAR-T cell technology is limited. This study developed bi-specific Trop2/PD-L1 specific third-generation CAR-T cells by lentiviral infection. The specific killing ability of the bi-specific CAR-T cells against Trop2

Keywords: Gastric cancer; PD-L1; Trop2; chimeric antigen receptors; immune microenvironment

Conflict of interest statement

None.

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