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Sadowski SM, Petrenko V, Meyer P, et al. Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates. Gland Surg. 2019;8:S62-S76doi: 10.21037/gs.2018.11.04.
Sadowski, S. M., Petrenko, V., Meyer, P., Pusztaszeri, M., Brulhart-Meynet, M. C., Heddad Masson, M., Triponez, F., Philippe, J., & Dibner, C. (2019). Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates. Gland surgery, 8S62-S76. https://doi.org/10.21037/gs.2018.11.04
Sadowski, Samira M, et al. "Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates." Gland surgery vol. 8 (2019): S62-S76. doi: https://doi.org/10.21037/gs.2018.11.04
Sadowski SM, Petrenko V, Meyer P, Pusztaszeri M, Brulhart-Meynet MC, Heddad Masson M, Triponez F, Philippe J, Dibner C. Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates. Gland Surg. 2019 Aug;8:S62-S76. doi: 10.21037/gs.2018.11.04. PMID: 31475093; PMCID: PMC6694023.
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Gland Surg. 2019 Aug;8:S62-S76. doi: 10.21037/gs.2018.11.04.

Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates.

Gland surgery

Samira M Sadowski, Volodymyr Petrenko, Patrick Meyer, Marc Pusztaszeri, Marie-Claude Brulhart-Meynet, Mounia Heddad Masson, Frédéric Triponez, Jacques Philippe, Charna Dibner

Affiliations

  1. Department of Thoracic and Endocrine Surgery, University Hospital of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  2. Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland.
  3. Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  4. Diabetes Centre, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  5. iGE3 Center, Geneva, Switzerland.
  6. Department of Pathology, Jewish General Hospital and McGill University, Montreal, Canada.

PMID: 31475093 PMCID: PMC6694023 DOI: 10.21037/gs.2018.11.04

Abstract

BACKGROUND: Despite substantial efforts, reliable preoperative diagnostic for human thyroid malignancies in case of cytologically indeterminate nodules is still missing, resulting in high number of unnecessary thyroidectomies. In an attempt to increase precision of existing preoperative diagnostics, we aimed at validating the panel of molecular biomarkers predictive for papillary thyroid carcinoma (PTC) in preoperative fine needle aspirate (FNA) samples.

METHODS: In this prospective study conducted in preoperative thyroid FNA from 44 thyroid nodules, expression levels of 11 molecular biomarkers previously validated on the postoperative samples of PTCs were measured by Cell-to-CT and QuantiGene Plex methods and correlated with final diagnosis.

RESULTS: The QuantiGene Plex resulted in reliable gene expression measurements for FNA and core-needle biopsy (CNB) samples, however this method was less sensitive than pre-amplification based Cell-to-CT. Measurements conducted on the same samples by the two methods significantly correlated for most of the genes. Expression levels of

CONCLUSIONS: Assessment of

Keywords: Papillary thyroid cancer (PTC); biomarkers; fine needle aspirates (FNAs); preoperative diagnostics

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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