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Verkouter I, Noordam R, le Cessie S, et al. The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat. J Clin Med. 2019;8(10)doi: 10.3390/jcm8101559.
Verkouter, I., Noordam, R., le Cessie, S., van Dam, R. M., Lamb, H. J., Rosendaal, F. R., van Heemst, D., & de Mutsert, R. (2019). The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat. Journal of clinical medicine, 8(10), . https://doi.org/10.3390/jcm8101559
Verkouter, Inge, et al. "The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat." Journal of clinical medicine vol. 8,10 (2019). doi: https://doi.org/10.3390/jcm8101559
Verkouter I, Noordam R, le Cessie S, van Dam RM, Lamb HJ, Rosendaal FR, van Heemst D, de Mutsert R. The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat. J Clin Med. 2019 Sep 28;8(10). doi: 10.3390/jcm8101559. PMID: 31569345; PMCID: PMC6832997.
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J Clin Med. 2019 Sep 28;8(10). doi: 10.3390/jcm8101559.

The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat.

Journal of clinical medicine

Inge Verkouter, Raymond Noordam, Saskia le Cessie, Rob M van Dam, Hildo J Lamb, Frits R Rosendaal, Diana van Heemst, Renée de Mutsert

Affiliations

  1. Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. [email protected].
  2. Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. [email protected].
  3. Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  4. Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  5. Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 117549, Singapore. [email protected].
  6. Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. [email protected].
  7. Department of Clinical Epidemiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. [email protected].
  8. Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. [email protected].

PMID: 31569345 PMCID: PMC6832997 DOI: 10.3390/jcm8101559

Abstract

We aimed to investigate the role of the amount of visceral fat and liver fat in the association between adult weight change and insulin resistance at middle age. In the Netherlands Epidemiology of Obesity study, adult weight change was calculated with recalled body weight at age 20 years and measured body weight at middle age. Measures of insulin resistance were calculated using both fasting and postprandial glucose and insulin concentrations. Visceral fat was assessed by magnetic resonance (MR) imaging and liver fat by proton-MR spectroscopy (

Keywords: body weight changes; fatty liver; insulin resistance; visceral fat

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