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Treisman DM, Li Y, Pierce BR, et al. Sox2. Neurooncol Adv. 2019;1(1):vdz027doi: 10.1093/noajnl/vdz027.
Treisman, D. M., Li, Y., Pierce, B. R., Li, C., Chervenak, A. P., Tomasek, G. J., Lozano, G., Zheng, X., Kool, M., & Zhu, Y. (2019). Sox2. Neuro-oncology advances, 1(1), vdz027. https://doi.org/10.1093/noajnl/vdz027
Treisman, Daniel M, et al. "Sox2." Neuro-oncology advances vol. 1,1 (2019): vdz027. doi: https://doi.org/10.1093/noajnl/vdz027
Treisman DM, Li Y, Pierce BR, Li C, Chervenak AP, Tomasek GJ, Lozano G, Zheng X, Kool M, Zhu Y. Sox2. Neurooncol Adv. 2019 May-Dec;1(1):vdz027. doi: 10.1093/noajnl/vdz027. Epub 2019 Sep 23. PMID: 31763624; PMCID: PMC6860004.
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Neurooncol Adv. 2019 May-Dec;1(1):vdz027. doi: 10.1093/noajnl/vdz027. Epub 2019 Sep 23.

Sox2.

Neuro-oncology advances

Daniel M Treisman, Yinghua Li, Brianna R Pierce, Chaoyang Li, Andrew P Chervenak, Gerald J Tomasek, Guillermina Lozano, Xiaoyan Zheng, Marcel Kool, Yuan Zhu

Affiliations

  1. Cellular and Molecular Biology Graduate Program, Ann Arbor, Michigan.
  2. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
  3. Gilbert Family Neurofibromatosis Institute, Washington, DC.
  4. Center for Cancer and Immunology Research, Washington, DC.
  5. Center for Neuroscience Research, Children's National Medical Center, Washington, DC.
  6. Department of Molecular Genetics, Section of Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  7. Department of Anatomy and Cell Biology, The GW School of Medicine and Health Sciences, The GW Cancer Center, Washington, DC.
  8. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.

PMID: 31763624 PMCID: PMC6860004 DOI: 10.1093/noajnl/vdz027

Abstract

BACKGROUND: High-intensity therapy effectively treats most

METHODS: Using mouse SHH-MB models with different p53 activities, we investigated therapeutic efficacy by activating p53-mediated cell-cycle arrest versus p53-mediated apoptosis on radiation-induced recurrence.

RESULTS: Upon radiation treatment, p53

CONCLUSIONS: Quiescent Sox2

© The Author(s) 2019. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

Keywords: Sonic Hedgehog medulloblastoma; apoptosis; granule cell precursor; neural precursor; p53

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