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Ekoru K, Doumatey A, Bentley AR, et al. Type 2 diabetes complications and comorbidity in Sub-Saharan Africans. EClinicalMedicine. 2019;16:30-41doi: 10.1016/j.eclinm.2019.09.001.
Ekoru, K., Doumatey, A., Bentley, A. R., Chen, G., Zhou, J., Shriner, D., Fasanmade, O., Okafor, G., Eghan, B., Agyenim-Boateng, K., Adeleye, J., Balogun, W., Amoah, A., Acheampong, J., Johnson, T., Oli, J., Adebamowo, C., Collins, F., Dunston, G., Adeyemo, A., & Rotimi, C. (2019). Type 2 diabetes complications and comorbidity in Sub-Saharan Africans. EClinicalMedicine, 1630-41. https://doi.org/10.1016/j.eclinm.2019.09.001
Ekoru, Kenneth, et al. "Type 2 diabetes complications and comorbidity in Sub-Saharan Africans." EClinicalMedicine vol. 16 (2019): 30-41. doi: https://doi.org/10.1016/j.eclinm.2019.09.001
Ekoru K, Doumatey A, Bentley AR, Chen G, Zhou J, Shriner D, Fasanmade O, Okafor G, Eghan B, Agyenim-Boateng K, Adeleye J, Balogun W, Amoah A, Acheampong J, Johnson T, Oli J, Adebamowo C, Collins F, Dunston G, Adeyemo A, Rotimi C. Type 2 diabetes complications and comorbidity in Sub-Saharan Africans. EClinicalMedicine. 2019 Oct 17;16:30-41. doi: 10.1016/j.eclinm.2019.09.001. eCollection 2019 Nov. PMID: 31832618; PMCID: PMC6890980.
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EClinicalMedicine. 2019 Oct 17;16:30-41. doi: 10.1016/j.eclinm.2019.09.001. eCollection 2019 Nov.

Type 2 diabetes complications and comorbidity in Sub-Saharan Africans.

EClinicalMedicine

Kenneth Ekoru, Ayo Doumatey, Amy R Bentley, Guanjie Chen, Jie Zhou, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, Francis Collins, Georgia Dunston, Adebowale Adeyemo, Charles Rotimi

Affiliations

  1. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  2. University of Lagos, Lagos, Nigeria.
  3. University of Nigeria Teaching Hospital, Enugu, Nigeria.
  4. University of Science and Technology, Kumasi, Ghana.
  5. University of Ibadan, Ibadan, Nigeria.
  6. University of Ghana Medical School, Accra, Ghana.
  7. Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD, USA.
  8. National Institutes of Health, Bethesda, MD, USA.
  9. National Human Genome Center at Howard University, Washington, DC, USA.

PMID: 31832618 PMCID: PMC6890980 DOI: 10.1016/j.eclinm.2019.09.001

Abstract

BACKGROUND: Context-specific evidence of the spectrum of type 2 diabetes (T2D) burden is essential for setting priorities and designing interventions to reduce associated morbidity and mortality. However, there are currently limited data on the burden of T2D complications and comorbidity in sub-Saharan Africa (SSA).

METHODS: T2D complications and comorbidities were assessed in 2,784 participants with diabetes enrolled from tertiary health centres and contextualised in 3,209 individuals without diabetes in Nigeria, Ghana and Kenya. T2D complications and comorbidities evaluated included cardiometabolic, ocular, neurological and renal characteristics.

FINDINGS: The most common complications/comorbidities among the T2D participants were hypertension (71%; 95% CI 69-73), hyperlipidaemia (34%; 95% CI 32-36), and obesity (27%; 95% CI 25-29). Additionally, the prevalence of cataracts was 32% (95% CI 30-35), diabetic retinopathy 15% (95% CI 13-17), impaired renal function 13% (95% CI 12-15), and erectile dysfunction (in men) 35% (95% CI 32-38). T2D population-attributable fraction for these comorbidities ranged between 6 and 64%.

INTERPRETATION: The burden of diabetes complications and comorbidity is substantial in SSA highlighting the urgent need for innovative public health strategies that prioritise promotion of healthy lifestyles for prevention and early detection of T2D. Also needed are strategies to strengthen health care system capacities to provide treatment and care for diabetes complications.

© 2019 Published by Elsevier Ltd.

Keywords: Co-morbidity; Complications; Epidemiology; Sub-Sahara Africa; Type 2 Diabetes

Conflict of interest statement

The authors declare no competing interests.

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