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Showing 1 to 12 of 18 entries
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Circulating adiponectin is associated with renal function independent of age and serum lipids in west africans.

International journal of nephrology

Doumatey AP, Zhou J, Huang H, Adeleye J, Balogun W, Fasanmade O, Johnson T, Oli J, Okafor G, Amoah A, Eghan B, Agyenim-Boateng K, Acheampong J, Adebamowo C, Adeyemo A, Rotimi CN.
PMID: 22957255
Int J Nephrol. 2012;2012:730920. doi: 10.1155/2012/730920. Epub 2012 Aug 22.

Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed...

Genome-wide association study for proliferative diabetic retinopathy in Africans.

NPJ genomic medicine

Liu C, Chen G, Bentley AR, Doumatey A, Zhou J, Adeyemo A, Yang J, Rotimi C.
PMID: 31482010
NPJ Genom Med. 2019 Aug 29;4:20. doi: 10.1038/s41525-019-0094-7. eCollection 2019.

Proliferative diabetic retinopathy (PDR) is a sight-threatening complication of diabetes that is associated with longer duration of diabetes and poor glycemic control under a genetic susceptibility background. Although GWAS of PDR have been conducted in Europeans and Asians, none...

Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.

Nature communications

Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Gourraud PA, Hansel NN, Hernandez RD, Herrera-Paz EF, Jiménez S, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Lizee A, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O'Connor TD, Oliveira RR, Olopade CO, Olopade O, Qin ZS, Rotimi C, Vince N, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, Mathias RA, Barnes KC.
PMID: 31484942
Nat Commun. 2019 Sep 04;10(1):4082. doi: 10.1038/s41467-019-12158-w.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.

International journal of nephrology

Bentley AR, Doumatey AP, Chen G, Huang H, Zhou J, Shriner D, Jiang C, Zhang Z, Liu G, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA, Agyenim-Boateng K, Adeleye J, Balogun W, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN.
PMID: 22973513
Int J Nephrol. 2012;2012:748984. doi: 10.1155/2012/748984. Epub 2012 Sep 02.

Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n...

Exploration of Epigenetics for Improvement of Drought and Other Stress Resistance in Crops: A Review.

Plants (Basel, Switzerland)

Sun C, Ali K, Yan K, Fiaz S, Dormatey R, Bi Z, Bai J.
PMID: 34208642
Plants (Basel). 2021 Jun 16;10(6). doi: 10.3390/plants10061226.

Crop plants often have challenges of biotic and abiotic stresses, and they adapt sophisticated ways to acclimate and cope with these through the expression of specific genes. Changes in chromatin, histone, and DNA mostly serve the purpose of combating...

Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.

Journal of endocrinology and metabolism

Doumatey AP, Xu H, Huang H, Trivedi NS, Lei L, Elkahloun A, Adeyemo A, Rotimi CN.
PMID: 26504501
J Endocrinol Metab. 2015 Jun;5(3):199-210. doi: 10.14740/jem286w.

BACKGROUND: Adipose tissues play important role in the pathophysiology of obesity-related diseases including type 2 diabetes (T2D). To describe gene expression patterns and functional pathways in obesity-related T2D, we performed global transcript profiling of omental adipose tissue (OAT) in...

Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention.

CVD prevention and control

Sumner AE, Zhou J, Doumatey A, Imoisili OE, Amoah A, Acheampong J, Oli J, Johnson T, Adebamowo C, Rotimi CN.
PMID: 21113431
CVD Prev Control. 2010 Sep 01;5(3):75-80. doi: 10.1016/j.cvdpc.2010.07.003.

BACKGROUND: Although designed to predict cardiovascular disease and type 2 diabetes mellitus, the Metabolic Syndrome (MetSyn) under-predicts these conditions in African-Americans (AA). Failure of MetSyn in AA is often attributed to their relative absence of hypertriglyceridemia. It is unknown...

Phenotypic variance explained by local ancestry in admixed African Americans.

Frontiers in genetics

Shriner D, Bentley AR, Doumatey AP, Chen G, Zhou J, Adeyemo A, Rotimi CN.
PMID: 26579196
Front Genet. 2015 Oct 29;6:324. doi: 10.3389/fgene.2015.00324. eCollection 2015.

We surveyed 26 quantitative traits and disease outcomes to understand the proportion of phenotypic variance explained by local ancestry in admixed African Americans. After inferring local ancestry as the number of African-ancestry chromosomes at hundreds of thousands of genotyped...

Type 2 diabetes complications and comorbidity in Sub-Saharan Africans.

EClinicalMedicine

Ekoru K, Doumatey A, Bentley AR, Chen G, Zhou J, Shriner D, Fasanmade O, Okafor G, Eghan B, Agyenim-Boateng K, Adeleye J, Balogun W, Amoah A, Acheampong J, Johnson T, Oli J, Adebamowo C, Collins F, Dunston G, Adeyemo A, Rotimi C.
PMID: 31832618
EClinicalMedicine. 2019 Oct 17;16:30-41. doi: 10.1016/j.eclinm.2019.09.001. eCollection 2019 Nov.

BACKGROUND: Context-specific evidence of the spectrum of type 2 diabetes (T2D) burden is essential for setting priorities and designing interventions to reduce associated morbidity and mortality. However, there are currently limited data on the burden of T2D complications and...

Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.

Genome medicine

Meeks KAC, Bentley AR, Gouveia MH, Chen G, Zhou J, Lei L, Adeyemo AA, Doumatey AP, Rotimi CN.
PMID: 34620218
Genome Med. 2021 Oct 07;13(1):156. doi: 10.1186/s13073-021-00971-2.

BACKGROUND: A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly...

A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals.

NPJ genomic medicine

Chen G, Adeyemo A, Zhou J, Doumatey AP, Bentley AR, Ekoru K, Shriner D, Rotimi CN.
PMID: 34117260
NPJ Genom Med. 2021 Jun 11;6(1):44. doi: 10.1038/s41525-021-00208-6.

Serum bilirubin is associated with several clinical outcomes, including hypertension, type 2 diabetes (T2D), and drug metabolism. Here, we describe findings from our genome-wide association studies (GWAS) of serum (TBIL) using a generalized linear mixed model in West Africans...

PeerJ

Dormatey R, Sun C, Ali K, Fiaz S, Xu D, Calderón-Urrea A, Bi Z, Zhang J, Bai J.
PMID: 34395075
PeerJ. 2021 Jul 27;9:e11809. doi: 10.7717/peerj.11809. eCollection 2021.

Antibiotic and herbicide resistance genes are the most common marker genes for plant transformation to improve crop yield and food quality. However, there is public concern about the use of resistance marker genes in food crops due to the...

Showing 1 to 12 of 18 entries