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Doumatey AP, Zhou J, Huang H, et al. Circulating adiponectin is associated with renal function independent of age and serum lipids in west africans. Int J Nephrol. 2012;2012:730920doi: 10.1155/2012/730920.
Doumatey, A. P., Zhou, J., Huang, H., Adeleye, J., Balogun, W., Fasanmade, O., Johnson, T., Oli, J., Okafor, G., Amoah, A., Eghan, B., Agyenim-Boateng, K., Acheampong, J., Adebamowo, C., Adeyemo, A., & Rotimi, C. N. (2012). Circulating adiponectin is associated with renal function independent of age and serum lipids in west africans. International journal of nephrology, 2012730920. https://doi.org/10.1155/2012/730920
Doumatey, A P, et al. "Circulating adiponectin is associated with renal function independent of age and serum lipids in west africans." International journal of nephrology vol. 2012 (2012): 730920. doi: https://doi.org/10.1155/2012/730920
Doumatey AP, Zhou J, Huang H, Adeleye J, Balogun W, Fasanmade O, Johnson T, Oli J, Okafor G, Amoah A, Eghan B, Agyenim-Boateng K, Acheampong J, Adebamowo C, Adeyemo A, Rotimi CN. Circulating adiponectin is associated with renal function independent of age and serum lipids in west africans. Int J Nephrol. 2012;2012:730920. doi: 10.1155/2012/730920. Epub 2012 Aug 22. PMID: 22957255; PMCID: PMC3432369.
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Int J Nephrol. 2012;2012:730920. doi: 10.1155/2012/730920. Epub 2012 Aug 22.

Circulating adiponectin is associated with renal function independent of age and serum lipids in west africans.

International journal of nephrology

A P Doumatey, J Zhou, H Huang, J Adeleye, W Balogun, O Fasanmade, T Johnson, J Oli, G Okafor, A Amoah, B Eghan, K Agyenim-Boateng, J Acheampong, C Adebamowo, A Adeyemo, C N Rotimi

Affiliations

  1. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20852, USA.

PMID: 22957255 PMCID: PMC3432369 DOI: 10.1155/2012/730920

Abstract

Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular. Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans. Total adiponectin was measured in 792 participants. MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function. Linear and logistic regression models were used to determine the relationship between adiponectin and renal function. Adiponectin showed an inverse relationship with eGFR in univariate (Beta(MDRD) = -0.18, Beta(CG) = -0.26) and multivariate (Beta(MDRD) = -0.10, Beta(CG) = -0.09) regression analyses. The multivariate models that included age, sex, BMI, hypertension, smoking, HDL-C, LDL-C, triglycerides, and adiponectin explained 30% and 55.6% of the variance in GFR estimated by MDRD and CG methods, respectively. Adiponectin was also a strong predictor of moderate chronic kidney disease (defined as eGFR < 60 mL/min/1.73 m(2)). We demonstrate that adiponectin is associated with renal function in nondiabetic West Africans. The observed relationship is independent of age and serum lipids. Our findings suggest that adiponectin may have clinical utility as a biomarker of renal function.

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