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Bentley AR, Doumatey AP, Chen G, et al. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. Int J Nephrol. 2012;2012:748984doi: 10.1155/2012/748984.
Bentley, A. R., Doumatey, A. P., Chen, G., Huang, H., Zhou, J., Shriner, D., Jiang, C., Zhang, Z., Liu, G., Fasanmade, O., Johnson, T., Oli, J., Okafor, G., Eghan, B. A., Agyenim-Boateng, K., Adeleye, J., Balogun, W., Adebamowo, C., Amoah, A., Acheampong, J., Adeyemo, A., & Rotimi, C. N. (2012). Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. International journal of nephrology, 2012748984. https://doi.org/10.1155/2012/748984
Bentley, Amy Rebecca, et al. "Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association." International journal of nephrology vol. 2012 (2012): 748984. doi: https://doi.org/10.1155/2012/748984
Bentley AR, Doumatey AP, Chen G, Huang H, Zhou J, Shriner D, Jiang C, Zhang Z, Liu G, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA, Agyenim-Boateng K, Adeleye J, Balogun W, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. Int J Nephrol. 2012;2012:748984. doi: 10.1155/2012/748984. Epub 2012 Sep 02. PMID: 22973513; PMCID: PMC3438781.
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Int J Nephrol. 2012;2012:748984. doi: 10.1155/2012/748984. Epub 2012 Sep 02.

Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.

International journal of nephrology

Amy Rebecca Bentley, Ayo P Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, Congqing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N Rotimi

Affiliations

  1. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-5635, USA.

PMID: 22973513 PMCID: PMC3438781 DOI: 10.1155/2012/748984

Abstract

Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n = 1100), West Africans (WA, n = 1497), and African Americans (AA, n = 1539). There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β = 0.13, P < 0.0001), but negatively associated among African ancestry populations (WA: -0.19, P < 0.0001; AA: -0.09, P = 0.02). These differences were also seen in nationally-representative NHANES data (among European Americans: 0.09, P = 0.005; among African Americans -0.14, P = 0.03). To further explore the findings in African ancestry populations, we investigated the role of an African ancestry-specific nephropathy risk variant, rs73885319, in the gene encoding HDL-associated APOL1. Among AA, an inverse HDLc-eGFR association was observed only with the risk genotype (-0.38 versus 0.001; P = 0.03). This interaction was not seen in WA. In summary, counter to expectation, an inverse HDLc-eGFR association was observed among those of African ancestry. Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association. Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc.

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