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Front Neurosci. 2019 Dec 06;13:1305. doi: 10.3389/fnins.2019.01305. eCollection 2019.

Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves.

Frontiers in neuroscience

Alexandra E Soto-Piña, Cynthia Franklin, C S Sheela Rani, Elizabeth Fernandez, Elías Cardoso-Peña, Alejandra D Benítez-Arciniega, Helmut Gottlieb, Carmen Hinojosa-Laborde, Randy Strong

Affiliations

  1. Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, Mexico.
  2. Feik School of Pharmacy, University of the Incarnate Word, San Antonio, TX, United States.
  3. Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
  4. Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, TX, United States.
  5. Unidad de Medicina Familiar 220, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

PMID: 31866814 PMCID: PMC6909820 DOI: 10.3389/fnins.2019.01305

Abstract

Synthetic glucocorticoids (GCs) are widely used to treat inflammatory conditions. However, chronic use of GCs can lead to hypertension. The cause of this undesired side effect remains unclear. Previously, we developed an

Copyright © 2019 Soto-Piña, Franklin, Rani, Fernandez, Cardoso-Peña, Benítez-Arciniega, Gottlieb, Hinojosa-Laborde and Strong.

Keywords: 6-OHDA; adrenal medulla; dexamethasone; hypertension; renal denervation; sympathetic nerves

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