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Li J, Zhang W, Zhu S, et al. Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats. Animals (Basel). 2020;10(2)doi: 10.3390/ani10020248.
Li, J., Zhang, W., Zhu, S., & Shi, F. (2020). Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats. Animals : an open access journal from MDPI, 10(2), . https://doi.org/10.3390/ani10020248
Li, Junrong, et al. "Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats." Animals : an open access journal from MDPI vol. 10,2 (2020). doi: https://doi.org/10.3390/ani10020248
Li J, Zhang W, Zhu S, Shi F. Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats. Animals (Basel). 2020 Feb 05;10(2). doi: 10.3390/ani10020248. PMID: 32033275; PMCID: PMC7070647.
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Animals (Basel). 2020 Feb 05;10(2). doi: 10.3390/ani10020248.

Nitric Oxide Synthase Is Involved in Follicular Development via the PI3K/AKT/FoxO3a Pathway in Neonatal and Immature Rats.

Animals : an open access journal from MDPI

Junrong Li, Wei Zhang, Shanli Zhu, Fangxiong Shi

Affiliations

  1. College of Agriculture and Bio-Engineering, Jinhua Polytechnic, Jinhua 321017, China.
  2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

PMID: 32033275 PMCID: PMC7070647 DOI: 10.3390/ani10020248

Abstract

It is assumed that nitric oxide synthase and nitric oxide are involved in the regulation of female reproduction. This study aimed to assess the roles of nitric oxide synthase (NOS) in follicular development. The endothelial NOS (eNOS) inhibitor L-NAME, inducible NOS (iNOS) inhibitor S-Methylisothiourea (SMT) and NOS substrate L-arginine (L-Arg) were used in the NOS inhibition models in vivo. Neonatal female rats were treated with phosphate buffer saline (PBS, control), L-NAME (L-NG-Nitroarginine Methyl Ester, 40 mg/kg), SMT (S-Methylisothiourea, 10 mg/kg), L-NAME + SMT, or L-Arg (L-arginine, 50 mg/kg) via subcutaneous (SC) injection on a daily basis for 19 consecutive days, with the samples being collected on specific postnatal days (PD5, PD10, and PD19). The results indicated that the number of antral follicles, the activity of total-NOS, iNOS, neuronal NOS (nNOS), and eNOS, and the content of NO in the ovary were significantly (

Keywords: AKT; FoxO3a; PTEN; follicular development; nitric oxide synthase

Conflict of interest statement

The authors declare no conflicts of interest.

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