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Malik A, Kardashian AA, Zakharia K, et al. Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist. Liver Res. 2019;3(2):118-127doi: 10.1016/j.livres.2019.04.001.
Malik, A., Kardashian, A. A., Zakharia, K., Bowlus, C. L., & Tabibian, J. H. (2019). Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist. Liver research, 3(2), 118-127. https://doi.org/10.1016/j.livres.2019.04.001
Malik, Adnan, et al. "Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist." Liver research vol. 3,2 (2019): 118-127. doi: https://doi.org/10.1016/j.livres.2019.04.001
Malik A, Kardashian AA, Zakharia K, Bowlus CL, Tabibian JH. Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist. Liver Res. 2019 Jun;3(2):118-127. doi: 10.1016/j.livres.2019.04.001. Epub 2019 May 27. PMID: 32042471; PMCID: PMC7008979.
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Liver Res. 2019 Jun;3(2):118-127. doi: 10.1016/j.livres.2019.04.001. Epub 2019 May 27.

Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist.

Liver research

Adnan Malik, Ani A Kardashian, Kais Zakharia, Christopher L Bowlus, James H Tabibian

Affiliations

  1. Department of Public Health and Business Administration, The University of Alabama at Birmingham, Birmingham, AL, USA.
  2. Department of Internal Medicine, Beaumont Hospital, Dearborn, MI, USA.
  3. University of California Los Angeles Gastroenterology Fellowship Training Program, Vatche and Tamar Manoukian Division of Digestive Diseases, Los Angeles, CA, USA.
  4. Division of Gastroenterology and Hepatology, University of Iowa, Iowa, IA, USA.
  5. Division of Gastroenterology and Hepatology, University of California Davis, Sacramento, CA, USA.
  6. Division of Gastroenterology, Department of Medicine, Olive View-University of California Los Angeles Medical Center, Sylmar, CA, USA.

PMID: 32042471 PMCID: PMC7008979 DOI: 10.1016/j.livres.2019.04.001

Abstract

Cholestatic liver diseases (CLDs) encompass a variety of disorders of abnormal bile formation and/or flow. CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications. Many such complications are clinically silent until they manifest with severe sequelae, including but not limited to life-altering symptoms, metabolic disturbances, cirrhosis, and hepatobiliary diseases as well as other malignancies. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common CLDs, and both relate to mutual as well as unique complications. This review provides an overview of PSC and PBC, with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications.

Keywords: Biliary tract diseases; Cirrhosis; Inflammatory bowel disease (IBD); Metabolic bone disease; Primary biliary cholangitis (PBC); Primary sclerosing cholangitis (PSC); Prophylaxis; Pruritus

Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

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