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Showing 1 to 12 of 197 entries
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Integration of Immune Cell Populations, mRNA-Seq, and CpG Methylation to Better Predict Humoral Immunity to Influenza Vaccination: Dependence of mRNA-Seq/CpG Methylation on Immune Cell Populations.

Frontiers in immunology

Zimmermann MT, Kennedy RB, Grill DE, Oberg AL, Goergen KM, Ovsyannikova IG, Haralambieva IH, Poland GA.
PMID: 28484452
Front Immunol. 2017 Apr 21;8:445. doi: 10.3389/fimmu.2017.00445. eCollection 2017.

The development of a humoral immune response to influenza vaccines occurs on a multisystems level. Due to the orchestration required for robust immune responses when multiple genes and their regulatory components across multiple cell types are involved, we examined...

Analysis of Left Atrial Respiratory and Cardiac Motion for Cardiac Ablation Therapy.

Proceedings of SPIE--the International Society for Optical Engineering

Rettmann ME, Holmes DR, Johnson SB, Lehmann HI, Robb RA, Packer DL.
PMID: 26405370
Proc SPIE Int Soc Opt Eng. 2015 Feb 21;9415. doi: 10.1117/12.2081209.

Cardiac ablation therapy is often guided by models built from preoperative computed tomography (CT) or magnetic resonance imaging (MRI) scans. One of the challenges in guiding a procedure from a preoperative model is properly synching the preoperative models with...

Granular Quality Reporting for Cervical Cytology Testing.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Wagholikar KB, MacLaughlin KL, Chute CG, Greenes RA, Liu H, Chaudhry R.
PMID: 26306264
AMIA Jt Summits Transl Sci Proc. 2015 Mar 25;2015:178-82. eCollection 2015.

Quality reporting for cervical cancer prevention is focused on patients with normal cervical cytology, and excludes patients with cytological abnormalities that may be at higher risk. The major obstacles for granular reporting are the complexity of surveillance guidelines and...

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay.

Skeletal muscle

Bergen HR, Farr JN, Vanderboom PM, Atkinson EJ, White TA, Singh RJ, Khosla S, LeBrasseur NK.
PMID: 26180626
Skelet Muscle. 2015 Jul 15;5:21. doi: 10.1186/s13395-015-0047-5. eCollection 2015.

BACKGROUND: Myostatin is a protein synthesized and secreted by skeletal muscle that negatively regulates muscle mass. The extent to which circulating myostatin levels change in the context of aging is controversial, largely due to methodological barriers.METHODS: We developed a...

Fitness Level is Associated with Sex-Specific Regional Fat Differences in Normal Weight Young Adults.

Journal of endocrinology and diabetes

Bosch TA, Dengel DR, Ryder JR, Kelly AS, Chow L.
PMID: 27054196
J Endocrinol Diabetes. 2015;2(2). doi: 10.15226/2374-6890/2/3/00122. Epub 2015 May 20.

OBJECTIVES: To characterize regional body composition and insulin sensitivity differences between young adults who were normal weight with either high or low fitness determined by VODESIGN: A cross-sectional comparison of normal weight males and females with high or low...

Making sense of how HIV kills infected CD4 T cells: implications for HIV cure.

Molecular and cellular therapies

Cummins NW, Badley AD.
PMID: 26056587
Mol Cell Ther. 2014 Jul 03;2:20. doi: 10.1186/2052-8426-2-20. eCollection 2014.

Defining how HIV does, and does not, kill the host CD4 T cell that it infects is of paramount importance in an era when research is approaching a cure for infection. Three mutually exclusive pathways can lead to the...

Quantifying Intraoperative Workloads Across the Surgical Team Roles: Room for Better Balance?.

World journal of surgery

Yu D, Lowndes B, Thiels C, Bingener J, Abdelrahman A, Lyons R, Hallbeck S.
PMID: 26952115
World J Surg. 2016 Jul;40(7):1565-74. doi: 10.1007/s00268-016-3449-6.

BACKGROUND: Surgical performance, provider health, and patient safety can be compromised when workload demands exceed individual capability on the surgical team. The purpose of this study is to quantify and compare intraoperative workload among surgical team members.METHODS: Observations were...

Statistical competencies for medical research learners: What is fundamental?.

Journal of clinical and translational science

Enders FT, Lindsell CJ, Welty LJ, Benn EKT, Perkins SM, Mayo MS, Rahbar MH, Kidwell KM, Thurston SW, Spratt H, Grambow SC, Larson J, Carter RE, Pollock BH, Oster RA.
PMID: 29082029
J Clin Transl Sci. 2017 Jun;1(3):146-152. doi: 10.1017/cts.2016.31. Epub 2017 May 09.

INTRODUCTION: It is increasingly essential for medical researchers to be literate in statistics, but the requisite degree of literacy is not the same for every statistical competency in translational research. Statistical competency can range from 'fundamental' (necessary for all)...

Dissemination and implementation of comparative effectiveness evidence: key informant interviews with Clinical and Translational Science Award institutions.

Journal of comparative effectiveness research

Morrato EH, Concannon TW, Meissner P, Shah ND, Turner BJ.
PMID: 24236560
J Comp Eff Res. 2013 Mar;2(2):185-94. doi: 10.2217/cer.13.10.

AIM: To identify ongoing practices and opportunities for improving national comparative effectiveness research (CER) translation through dissemination and implementation (D&I) via NIH-funded Clinical and Translational Science Award (CTSA) institutions.MATERIALS & METHODS: Key informant interviews were conducted with 18 CTSA...

Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study.

Biology of sex differences

Jayachandran M, Lugo G, Heiling H, Miller VM, Rule AD, Lieske JC.
PMID: 25729563
Biol Sex Differ. 2015 Feb 24;6:2. doi: 10.1186/s13293-015-0021-2. eCollection 2015.

BACKGROUND: The lifetime incidence of kidney stones is about two times greater in men compared to women. Extracellular vesicles (EVs) shed from activated cells are present in the urine and may reflect or even mediate renal physiology and/or pathology....

Hyperandrogenism in female athletes with functional hypothalamic amenorrhea: a distinct phenotype.

International journal of women's health

Javed A, Kashyap R, Lteif AN.
PMID: 25610004
Int J Womens Health. 2015 Jan 13;7:103-11. doi: 10.2147/IJWH.S73011. eCollection 2015.

OBJECTIVE: To compare the reproductive, metabolic, and skeletal profiles of young athletic women with functional hypothalamic amenorrhea (FHA) as well as clinical or biochemical hyperandrogenism (FHA-EX+HA) with body mass index matched women with FHA due to exercise (FHA-EX) or...

Faculty perceptions of how community-engaged research is valued in tenure, promotion, and retention decisions.

Clinical and translational science

Nokes KM, Nelson DA, McDonald MA, Hacker K, Gosse J, Sanford B, Opel S.
PMID: 23919360
Clin Transl Sci. 2013 Aug;6(4):259-66. doi: 10.1111/cts.12077.

PURPOSE: We assessed the perceptions of community core faculty in academic medical center institutions that received Clinical and Translational Science Awards (CTSA) about how these institutions consider community-engaged scholarship (CES) when tenure, promotion, and retention decisions are made.METHOD: An...

Showing 1 to 12 of 197 entries