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Jiang Y, Zhang T, Kusumanchi P, et al. Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines. 2020;8(3)doi: 10.3390/biomedicines8030050.
Jiang, Y., Zhang, T., Kusumanchi, P., Han, S., Yang, Z., & Liangpunsakul, S. (2020). Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines, 8(3), . https://doi.org/10.3390/biomedicines8030050
Jiang, Yanchao, et al. "Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease." Biomedicines vol. 8,3 (2020). doi: https://doi.org/10.3390/biomedicines8030050
Jiang Y, Zhang T, Kusumanchi P, Han S, Yang Z, Liangpunsakul S. Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines. 2020 Mar 04;8(3). doi: 10.3390/biomedicines8030050. PMID: 32143280; PMCID: PMC7148483.
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Biomedicines. 2020 Mar 04;8(3). doi: 10.3390/biomedicines8030050.

Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease.

Biomedicines

Yanchao Jiang, Ting Zhang, Praveen Kusumanchi, Sen Han, Zhihong Yang, Suthat Liangpunsakul

Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  2. Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA.

PMID: 32143280 PMCID: PMC7148483 DOI: 10.3390/biomedicines8030050

Abstract

Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase

Keywords: alcohol metabolizing enzyme; and alcohol-associated liver disease; cytochrome P450 2E1

Conflict of interest statement

All authors declare no conflict of interest with this manuscript

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