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Chen S, Jain M, Jhangiani S, et al. Genetic Burden Contributing to Extremely Low or High Bone Mineral Density in a Senior Male Population From the Osteoporotic Fractures in Men Study (MrOS). JBMR Plus. 2020;4(3):e10335doi: 10.1002/jbm4.10335.
Chen, S., Jain, M., Jhangiani, S., Akdemir, Z. C., Campeau, P. M., Klein, R. F., Nielson, C., Dai, H., Muzny, D. M., Boerwinkle, E., Gibbs, R. A., Orwoll, E. S., Lupski, J. R., Posey, J. E., & Lee, B. (2020). Genetic Burden Contributing to Extremely Low or High Bone Mineral Density in a Senior Male Population From the Osteoporotic Fractures in Men Study (MrOS). JBMR plus, 4(3), e10335. https://doi.org/10.1002/jbm4.10335
Chen, Shan, et al. "Genetic Burden Contributing to Extremely Low or High Bone Mineral Density in a Senior Male Population From the Osteoporotic Fractures in Men Study (MrOS)." JBMR plus vol. 4,3 (2020): e10335. doi: https://doi.org/10.1002/jbm4.10335
Chen S, Jain M, Jhangiani S, Akdemir ZC, Campeau PM, Klein RF, Nielson C, Dai H, Muzny DM, Boerwinkle E, Gibbs RA, Orwoll ES, Lupski JR, Posey JE, Lee B. Genetic Burden Contributing to Extremely Low or High Bone Mineral Density in a Senior Male Population From the Osteoporotic Fractures in Men Study (MrOS). JBMR Plus. 2020 Jan 22;4(3):e10335. doi: 10.1002/jbm4.10335. eCollection 2020 Mar. PMID: 32161841; PMCID: PMC7059823.
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JBMR Plus. 2020 Jan 22;4(3):e10335. doi: 10.1002/jbm4.10335. eCollection 2020 Mar.

Genetic Burden Contributing to Extremely Low or High Bone Mineral Density in a Senior Male Population From the Osteoporotic Fractures in Men Study (MrOS).

JBMR plus

Shan Chen, Mahim Jain, Shalini Jhangiani, Zeynep C Akdemir, Philippe M Campeau, Robert F Klein, Carrie Nielson, Hongzheng Dai, Donna M Muzny, Eric Boerwinkle, Richard A Gibbs, Eric S Orwoll, James R Lupski, Jennifer E Posey, Brendan Lee

Affiliations

  1. Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
  2. Osteogenesis Imperfecta Clinic, Kennedy Krieger Institute Baltimore MD USA.
  3. Human Genome Sequencing Center Baylor College of Medicine Houston TX USA.
  4. University of Montreal Medical Genetics Service Montréal QC Canada.
  5. School of Medicine Oregon Health & Science University Portland OR USA.
  6. Human Genetics Center and Department of Epidemiology UTHealth School of Public Health Houston TX USA.
  7. Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital Houston TX USA.

PMID: 32161841 PMCID: PMC7059823 DOI: 10.1002/jbm4.10335

Abstract

Worldwide, one in five men aged over 50 years will experience osteoporosis or a clinical bone fracture, with a greater fracture-related mortality rate than women. However, the genetic etiology of osteoporosis in men is still poorly understood. We aimed to identify the genetic variants and candidate genes associated with extremely low or high BMD for a better understanding of the biology underlying low bone density that may point to potential therapeutic targets for increasing bone mass. Subjects from the Osteoporotic Fractures in Men Study (MrOS) cohort were evaluated by age and BMI-adjusted total hip BMD. Those with BMD values 3 SDs away from the mean were selected and the remaining individuals whose adjusted BMD ranked at the highest or lowest 100 were included. Men with the lowest adjusted BMD (

© 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

Keywords: ANALYSIS/QUANTITATION OF BONE; DISEASES AND DISORDERS OF/RELATED TO BONE; DXA; GENETIC RESEARCH; HUMAN ASSOCIATION STUDIES; OSTEOPOROSIS

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