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Adornetto A, Parisi V, Morrone LA, et al. The Role of Autophagy in Glaucomatous Optic Neuropathy. Front Cell Dev Biol. 2020;8:121doi: 10.3389/fcell.2020.00121.
Adornetto, A., Parisi, V., Morrone, L. A., Corasaniti, M. T., Bagetta, G., Tonin, P., & Russo, R. (2020). The Role of Autophagy in Glaucomatous Optic Neuropathy. Frontiers in cell and developmental biology, 8121. https://doi.org/10.3389/fcell.2020.00121
Adornetto, Annagrazia, et al. "The Role of Autophagy in Glaucomatous Optic Neuropathy." Frontiers in cell and developmental biology vol. 8 (2020): 121. doi: https://doi.org/10.3389/fcell.2020.00121
Adornetto A, Parisi V, Morrone LA, Corasaniti MT, Bagetta G, Tonin P, Russo R. The Role of Autophagy in Glaucomatous Optic Neuropathy. Front Cell Dev Biol. 2020 Mar 04;8:121. doi: 10.3389/fcell.2020.00121. eCollection 2020. PMID: 32211404; PMCID: PMC7066980.
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Front Cell Dev Biol. 2020 Mar 04;8:121. doi: 10.3389/fcell.2020.00121. eCollection 2020.

The Role of Autophagy in Glaucomatous Optic Neuropathy.

Frontiers in cell and developmental biology

Annagrazia Adornetto, Vincenzo Parisi, Luigi Antonio Morrone, Maria Tiziana Corasaniti, Giacinto Bagetta, Paolo Tonin, Rossella Russo

Affiliations

  1. Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, Rende, Italy.
  2. Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Rome, Italy.
  3. Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  4. Regional Center for Serious Brain Injuries, S. Anna Institute, Crotone, Italy.

PMID: 32211404 PMCID: PMC7066980 DOI: 10.3389/fcell.2020.00121

Abstract

Autophagy is a conserved lysosomal-dependent pathway responsible for the degradation of cytoplasmic macromolecules. Based on the mechanism of cargo delivery to lysosomes, mammalian cells can undergo micro, macro, and chaperone-mediated autophagy. Other than physiological turnover of proteins and organelles, autophagy regulates cellular adaptation to different metabolic states and stressful conditions by allowing cellular survival or, when overactivated, participating to cell death. Due to their structure and function, neurons are highly dependent on autophagy efficiency and dysfunction of the pathway has been associated with neurodegenerative disorders. Glaucomatous optic neuropathies, a leading cause of blindness, are characterized by the progressive loss of a selective population of retinal neurons, i.e., the retinal ganglion cells (RGCs). Here we review the current literature on the role of autophagy in the pathogenic process that leads to the degeneration of RGC in various experimental models of glaucoma exploring the modulation of the pathway as a potential therapeutic intervention.

Copyright © 2020 Adornetto, Parisi, Morrone, Corasaniti, Bagetta, Tonin and Russo.

Keywords: CMA; LC3; autophagy; glaucoma; mitophagy; p62; retina; retinal ganglion cells

References

  1. Exp Mol Med. 2019 Aug 13;51(8):1-11 - PubMed
  2. Curr Biol. 2013 Mar 4;23(5):430-5 - PubMed
  3. J Biol Chem. 2011 Feb 4;286(5):3618-29 - PubMed
  4. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48 - PubMed
  5. Prog Retin Eye Res. 2012 Mar;31(2):152-81 - PubMed
  6. J Ophthalmic Vis Res. 2016 Apr-Jun;11(2):204-8 - PubMed
  7. PLoS One. 2013 Oct 15;8(10):e77100 - PubMed
  8. Nat Rev Mol Cell Biol. 2018 Sep;19(9):579-593 - PubMed
  9. Cell Death Discov. 2018 Jul 17;4:14 - PubMed
  10. Exp Eye Res. 2017 May;158:146-153 - PubMed
  11. Biochim Biophys Acta. 2015 Mar;1852(3):379-85 - PubMed
  12. Mol Biol Cell. 2004 Nov;15(11):4829-40 - PubMed
  13. J Biol Chem. 2013 Apr 12;288(15):10703-14 - PubMed
  14. Mol Biol Cell. 2008 May;19(5):2179-92 - PubMed
  15. Mol Neurobiol. 2019 Sep;56(9):6586-6593 - PubMed
  16. Invest Ophthalmol Vis Sci. 2015 Feb 05;56(3):1437-46 - PubMed
  17. Sci Rep. 2016 Nov 25;6:37805 - PubMed
  18. Cell Death Dis. 2011 Apr 14;2:e144 - PubMed
  19. Int Rev Neurobiol. 2009;85:407-23 - PubMed
  20. Exp Eye Res. 2010 Jul;91(1):48-53 - PubMed
  21. Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2775-83 - PubMed
  22. Autophagy. 2007 Jul-Aug;3(4):323-8 - PubMed
  23. J Neurosci. 2019 May 1;39(18):3582-3596 - PubMed
  24. Am J Physiol. 1995 Nov;269(5 Pt 1):C1200-8 - PubMed
  25. PLoS One. 2014 Jun 12;9(6):e99719 - PubMed
  26. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13135-40 - PubMed
  27. Autophagy. 2016;12(1):1-222 - PubMed
  28. Autophagy. 2013 Apr;9(4):581-94 - PubMed
  29. Autophagy. 2019 Jul;15(7):1182-1198 - PubMed
  30. Exp Ther Med. 2015 Feb;9(2):476-482 - PubMed
  31. Cell Death Dis. 2018 Jan 24;9(2):88 - PubMed
  32. Autophagy. 2007 Jul-Aug;3(4):295-9 - PubMed
  33. Sci Rep. 2016 Sep 22;6:33830 - PubMed
  34. Nat Cell Biol. 2018 Sep;20(9):1013-1022 - PubMed
  35. Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2380-2387 - PubMed
  36. Cell Cycle. 2015;14(7):959-63 - PubMed
  37. Cell Death Dis. 2013 Oct 17;4:e860 - PubMed
  38. Antioxid Redox Signal. 2014 Jan 20;20(3):460-73 - PubMed
  39. Science. 2008 Nov 7;322(5903):963-6 - PubMed
  40. ASN Neuro. 2014 Dec 12;6(6): - PubMed
  41. Autophagy. 2010 Jul;6(5):658-9 - PubMed
  42. Hum Mol Genet. 2002 May 1;11(9):1107-17 - PubMed
  43. Ophthalmology. 2014 Nov;121(11):2081-90 - PubMed
  44. Nat Commun. 2011 Jul 12;2:386 - PubMed
  45. Biochem Soc Trans. 2001 Nov;29(Pt 6):812-7 - PubMed
  46. Cell Death Differ. 2012 Jan;19(1):162-9 - PubMed
  47. Neurosci Lett. 2014 Oct 3;581:37-41 - PubMed
  48. J Cell Sci. 2000 Dec;113 Pt 24:4441-50 - PubMed
  49. Adv Exp Med Biol. 2014;801:677-83 - PubMed
  50. PLoS One. 2011;6(7):e22514 - PubMed
  51. Science. 2002 Feb 8;295(5557):1077-9 - PubMed
  52. J Neurosci Res. 2008 Oct;86(13):2943-51 - PubMed
  53. J Mol Biol. 2016 May 8;428(9 Pt A):1714-24 - PubMed
  54. Neuron. 2017 Mar 8;93(5):1015-1034 - PubMed
  55. Sci Rep. 2018 Sep 6;8(1):13321 - PubMed
  56. Cell Death Dis. 2012 Apr 05;3:e290 - PubMed
  57. Autophagy. 2011 Aug;7(8):924-6 - PubMed
  58. Prog Brain Res. 2015;221:49-65 - PubMed
  59. Cell Death Dis. 2018 Sep 24;9(10):981 - PubMed
  60. Glia. 2012 Jan;60(1):13-28 - PubMed
  61. Autophagy. 2011 Jun;7(6):643-4 - PubMed
  62. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5805-10 - PubMed
  63. Aging Cell. 2013 Jun;12(3):478-88 - PubMed
  64. Nature. 2015 Aug 20;524(7565):309-314 - PubMed
  65. Autophagy. 2011 Mar;7(3):279-96 - PubMed

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