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Jensen RB, Rothenberg E. Preserving genome integrity in human cells via DNA double-strand break repair. Mol Biol Cell. 2020;31(9):859-865doi: 10.1091/mbc.E18-10-0668.
Jensen, R. B., & Rothenberg, E. (2020). Preserving genome integrity in human cells via DNA double-strand break repair. Molecular biology of the cell, 31(9), 859-865. https://doi.org/10.1091/mbc.E18-10-0668
Jensen, Ryan B, and Rothenberg, Eli. "Preserving genome integrity in human cells via DNA double-strand break repair." Molecular biology of the cell vol. 31,9 (2020): 859-865. doi: https://doi.org/10.1091/mbc.E18-10-0668
Jensen RB, Rothenberg E. Preserving genome integrity in human cells via DNA double-strand break repair. Mol Biol Cell. 2020 Apr 15;31(9):859-865. doi: 10.1091/mbc.E18-10-0668. PMID: 32286930; PMCID: PMC7185975.
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Mol Biol Cell. 2020 Apr 15;31(9):859-865. doi: 10.1091/mbc.E18-10-0668.

Preserving genome integrity in human cells via DNA double-strand break repair.

Molecular biology of the cell

Ryan B Jensen, Eli Rothenberg

Affiliations

  1. Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520-8040.
  2. Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.

PMID: 32286930 PMCID: PMC7185975 DOI: 10.1091/mbc.E18-10-0668

Abstract

The efficient maintenance of genome integrity in the face of cellular stress is vital to protect against human diseases such as cancer. DNA replication, chromatin dynamics, cellular signaling, nuclear architecture, cell cycle checkpoints, and other cellular activities contribute to the delicate spatiotemporal control that cells utilize to regulate and maintain genome stability. This perspective will highlight DNA double-strand break (DSB) repair pathways in human cells, how DNA repair failures can lead to human disease, and how PARP inhibitors have emerged as a novel clinical therapy to treat homologous recombination-deficient tumors. We briefly discuss how failures in DNA repair produce a permissive genetic environment in which preneoplastic cells evolve to reach their full tumorigenic potential. Finally, we conclude that an in-depth understanding of DNA DSB repair pathways in human cells will lead to novel therapeutic strategies to treat cancer and potentially other human diseases.

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