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Showing 1 to 12 of 32 entries
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The relationship between cell-free circulating DNA and inflammation in acute coronary syndrome.

Cardiology

Cui M, Jing R, Fan M, Zhu J, Ju S.
PMID: 23969759
Cardiology. 2013;126(2):124-5. doi: 10.1159/000353665. Epub 2013 Aug 17.

No abstract available.

Single-Nucleotide-Resolution Computing and Memory in Living Cells.

Molecular cell

Farzadfard F, Gharaei N, Higashikuni Y, Jung G, Cao J, Lu TK.
PMID: 31442423
Mol Cell. 2019 Aug 22;75(4):769-780.e4. doi: 10.1016/j.molcel.2019.07.011.

The ability to process and store information in living cells is essential for developing next-generation therapeutics and studying biology in situ. However, existing strategies have limited recording capacity and are challenging to scale. To overcome these limitations, we developed...

Highly Efficient Single-Pot Scarless Golden Gate Assembly.

ACS synthetic biology

HamediRad M, Weisberg S, Chao R, Lian J, Zhao H.
PMID: 31013062
ACS Synth Biol. 2019 May 17;8(5):1047-1054. doi: 10.1021/acssynbio.8b00480. Epub 2019 Apr 30.

Golden Gate assembly is one of the most widely used DNA assembly methods due to its robustness and modularity. However, despite its popularity, the need for BsaI-free parts, the introduction of scars between junctions, as well as the lack...

Search and Localization Dynamics of the CRISPR-Cas9 System.

Physical review letters

Lu Q, Bhat D, Stepanenko D, Pigolotti S.
PMID: 34860046
Phys Rev Lett. 2021 Nov 12;127(20):208102. doi: 10.1103/PhysRevLett.127.208102.

The CRISPR-Cas9 system acts as the prokaryotic immune system and has important applications in gene editing. The protein Cas9 is one of its crucial components. The role of Cas9 is to search for specific target sequences on the DNA...

Can Designer Indels Be Tailored by Gene Editing?: Can Indels Be Customized?.

BioEssays : news and reviews in molecular, cellular and developmental biology

Trimidal SG, Benjamin R, Bae JE, Han MV, Kong E, Singer A, Williams TS, Yang B, Schiller MR.
PMID: 31693213
Bioessays. 2019 Dec;41(12):e1900126. doi: 10.1002/bies.201900126. Epub 2019 Nov 06.

Genome editing with engineered nucleases (GEENs) introduce site-specific DNA double-strand breaks (DSBs) and repairs DSBs via nonhomologous end-joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be...

Preserving genome integrity in human cells via DNA double-strand break repair.

Molecular biology of the cell

Jensen RB, Rothenberg E.
PMID: 32286930
Mol Biol Cell. 2020 Apr 15;31(9):859-865. doi: 10.1091/mbc.E18-10-0668.

The efficient maintenance of genome integrity in the face of cellular stress is vital to protect against human diseases such as cancer. DNA replication, chromatin dynamics, cellular signaling, nuclear architecture, cell cycle checkpoints, and other cellular activities contribute to...

DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs.

Angewandte Chemie (International ed. in English)

Lerner RA, Brenner S.
PMID: 28094476
Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1164-1165. doi: 10.1002/anie.201612143.

"… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow...

Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior.

Physical review letters

Hoogerheide DP, Albertorio F, Golovchenko JA.
PMID: 24483704
Phys Rev Lett. 2013 Dec 13;111(24):248301. doi: 10.1103/PhysRevLett.111.248301. Epub 2013 Dec 12.

We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of...

Anomalous protein-DNA interactions behind neurological disorders.

Advances in protein chemistry and structural biology

Camero S, Benítez MJ, Jiménez JS.
PMID: 23790210
Adv Protein Chem Struct Biol. 2013;91:37-63. doi: 10.1016/B978-0-12-411637-5.00002-0.

Aggregation, nuclear location, and nucleic acid interaction are common features shared by a number of proteins related to neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, transmissible spongiform encephalopathy, Huntington's disease, spinobulbar muscular atrophy, dentatorubro-pallidoluysian atrophy, and...

DNA Capture by Nanopore Sensors under Flow.

Analytical chemistry

Sohi AN, Beamish E, Tabard-Cossa V, Godin M.
PMID: 32412730
Anal Chem. 2020 Jun 16;92(12):8108-8116. doi: 10.1021/acs.analchem.9b05778. Epub 2020 Jun 02.

Integrating nanopore sensors within microfluidic architectures is key to providing advanced sample processing capabilities upstream of the biosensor. When confined in a microchannel, the nanopore capture and translocation characteristics are altered when subjected to cross-flow, affecting sensor performance. Here,...

[Pathogenesis of hyperuricemia].

Naika. Internal medicine

Arima M, Aoki K.
PMID: 5542273
Naika. 1971 Feb;27(2):204-10.

No abstract available.

[Biosynthesis of DNA].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme

TAKAGI Y.
PMID: 13919023
Tanpakushitsu Kakusan Koso. 1961 Dec;6:705-12.

No abstract available.

Showing 1 to 12 of 32 entries