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Hoogerheide DP, Albertorio F, Golovchenko JA. Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior. Phys Rev Lett. 2013;111(24):248301doi: 10.1103/PhysRevLett.111.248301.
Hoogerheide, D. P., Albertorio, F., & Golovchenko, J. A. (2013). Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior. Physical review letters, 111(24), 248301. https://doi.org/10.1103/PhysRevLett.111.248301
Hoogerheide, David P, et al. "Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior." Physical review letters vol. 111,24 (2013): 248301. doi: https://doi.org/10.1103/PhysRevLett.111.248301
Hoogerheide DP, Albertorio F, Golovchenko JA. Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior. Phys Rev Lett. 2013 Dec 13;111(24):248301. doi: 10.1103/PhysRevLett.111.248301. Epub 2013 Dec 12. PMID: 24483704; PMCID: PMC4085674.
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Phys Rev Lett. 2013 Dec 13;111(24):248301. doi: 10.1103/PhysRevLett.111.248301. Epub 2013 Dec 12.

Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior.

Physical review letters

David P Hoogerheide, Fernando Albertorio, Jene A Golovchenko

Affiliations

  1. Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
  2. Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

PMID: 24483704 PMCID: PMC4085674 DOI: 10.1103/PhysRevLett.111.248301

Abstract

We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.

References

  1. Phys Rev Lett. 2009 Jun 26;102(25):256804 - PubMed
  2. Nat Nanotechnol. 2007 Dec;2(12):775-9 - PubMed
  3. Electrophoresis. 2007 Sep;28(18):3186-92 - PubMed
  4. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Mar;81(3 Pt 1):031803 - PubMed
  5. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2 Pt 1):021802 - PubMed
  6. Biophys J. 1999 Oct;77(4):1824-38 - PubMed
  7. Nat Biotechnol. 2008 Oct;26(10):1146-53 - PubMed
  8. J Chem Phys. 2010 Apr 28;132(16):164904 - PubMed
  9. Biopolymers. 1990 Jul-Aug 5;29(8-9):1167-73 - PubMed
  10. Phys Rev Lett. 2000 Oct 2;85(14):3057-60 - PubMed
  11. Chem Rev. 2012 Dec 12;112(12):6431-51 - PubMed
  12. Biophys J. 2008 Dec;95(11):5317-23 - PubMed
  13. Biophys J. 2011 Jul 6;101(1):70-9 - PubMed
  14. Nano Lett. 2005 Jul;5(7):1193-7 - PubMed
  15. Nat Mater. 2003 Sep;2(9):611-5 - PubMed
  16. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jul;86(1 Pt 1):011921 - PubMed
  17. J Am Chem Soc. 2010 Feb 17;132(6):1878-85 - PubMed
  18. Electrophoresis. 2001 Aug;22(12):2424-32 - PubMed
  19. Phys Rev Lett. 1996 Jul 22;77(4):783-786 - PubMed
  20. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13770-3 - PubMed
  21. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Jan;65(1 Pt 1):011802 - PubMed
  22. Nat Mater. 2003 Aug;2(8):537-40 - PubMed
  23. Biophys J. 2003 Apr;84(4):2366-72 - PubMed
  24. J Phys Condens Matter. 2011 Mar 16;23(10):103101 - PubMed
  25. Phys Rev Lett. 2003 Sep 26;91(13):138101 - PubMed
  26. Nature. 2001 Jul 12;412(6843):166-9 - PubMed

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