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Lerner RA, Brenner S. DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs. Angew Chem Int Ed Engl. 2017;56(5):1164-1165doi: 10.1002/anie.201612143.
Lerner, R. A., & Brenner, S. (2017). DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs. Angewandte Chemie (International ed. in English), 56(5), 1164-1165. https://doi.org/10.1002/anie.201612143
Lerner, Richard A, and Brenner, Sydney. "DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs." Angewandte Chemie (International ed. in English) vol. 56,5 (2017): 1164-1165. doi: https://doi.org/10.1002/anie.201612143
Lerner RA, Brenner S. DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs. Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1164-1165. doi: 10.1002/anie.201612143. PMID: 28094476.
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Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1164-1165. doi: 10.1002/anie.201612143.

DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs.

Angewandte Chemie (International ed. in English)

Richard A Lerner, Sydney Brenner

Affiliations

  1. The Scripps Research Institute, 10550 North Torrey Pines Road, MB-10, La Jolla, CA 92037, USA.

PMID: 28094476 DOI: 10.1002/anie.201612143

Abstract

"… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high-throughput screening centers …" Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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