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Wang JZ, Moody JB, Kaps N, et al. Reproducible Quantification of Regional Sympathetic Denervation with [. J Nucl Cardiol. 2020;doi: 10.1007/s12350-020-02114-3.
Wang, J. Z., Moody, J. B., Kaps, N., Britt, D., Lavallee, A., Renaud, J. M., Zelt, J. G. E., Wu, K. Y., Beanlands, R. S., Fallavollita, J. A., Canty, J. M., & deKemp, R. A. (2020). Reproducible Quantification of Regional Sympathetic Denervation with [. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, . https://doi.org/10.1007/s12350-020-02114-3
Wang, Jean Z, et al. "Reproducible Quantification of Regional Sympathetic Denervation with [." Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology vol. (2020). doi: https://doi.org/10.1007/s12350-020-02114-3
Wang JZ, Moody JB, Kaps N, Britt D, Lavallee A, Renaud JM, Zelt JGE, Wu KY, Beanlands RS, Fallavollita JA, Canty JM, deKemp RA. Reproducible Quantification of Regional Sympathetic Denervation with [. J Nucl Cardiol. 2020 Apr 28; doi: 10.1007/s12350-020-02114-3. Epub 2020 Apr 28. PMID: 32347526; PMCID: PMC7673573.
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J Nucl Cardiol. 2020 Apr 28; doi: 10.1007/s12350-020-02114-3. Epub 2020 Apr 28.

Reproducible Quantification of Regional Sympathetic Denervation with [.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Jean Z Wang, Jonathan B Moody, Nicole Kaps, Deron Britt, Aaryn Lavallee, Jennifer M Renaud, Jason G E Zelt, Kai Yi Wu, Rob S Beanlands, James A Fallavollita, John M Canty, Robert A deKemp

Affiliations

  1. Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
  2. Faculty of Medicine, University of Ottawa, Ottawa, Canada.
  3. INVIA Medical Imaging Solutions, Ann Arbor, Michigan, USA.
  4. Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
  5. Division of Cardiovascular Medicine, University at Buffalo, Buffalo, NY, USA.
  6. VA Western New York Healthcare System, Buffalo, NY, USA.
  7. Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. [email protected].

PMID: 32347526 PMCID: PMC7673573 DOI: 10.1007/s12350-020-02114-3

Abstract

BACKGROUND: Regional cardiac sympathetic denervation is predictive of sudden cardiac arrest in patients with ischemic cardiomyopathy. The reproducibility of denervation scores between automated software programs has not been evaluated. This study seeks to (1) compare the inter-rater reliability of regional denervation measurements using two analysis programs: FlowQuant

METHODS: N = 190 dynamic [

RESULTS: Inter-observer, inter-software, and test-retest ICC values were excellent (ICC = 94% to 99%) and measurement variability was small (RPC < 11%). Mean differences between observers ranged .2% to 1.1% for Corridor4DM (P = .28), FlowQuant (P < .001), and between software programs (P < .001). Kaplan-Meier analysis demonstrated HED scores from both programs were predictive of SCA.

CONCLUSION: Inter-rater reliability for both analysis programs was excellent and test-retest repeatability was consistent. The minimal difference in scores between FlowQuant and Corridor4DM supports their use in future trials.

Keywords: PET; cardiac innervation; innervation tracers

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