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Cheng S, Wen Y, Ma M, et al. Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets. Schizophr Bull. 2020;doi: 10.1093/schbul/sbaa053.
Cheng, S., Wen, Y., Ma, M., Zhang, L., Liu, L., Qi, X., Cheng, B., Liang, C., Li, P., Kafle, O. P., & Zhang, F. (2020). Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets. Schizophrenia bulletin, . https://doi.org/10.1093/schbul/sbaa053
Cheng, Shiqiang, et al. "Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets." Schizophrenia bulletin vol. (2020). doi: https://doi.org/10.1093/schbul/sbaa053
Cheng S, Wen Y, Ma M, Zhang L, Liu L, Qi X, Cheng B, Liang C, Li P, Kafle OP, Zhang F. Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets. Schizophr Bull. 2020 Apr 15; doi: 10.1093/schbul/sbaa053. Epub 2020 Apr 15. PMID: 32291453; PMCID: PMC7505178.
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Schizophr Bull. 2020 Apr 15; doi: 10.1093/schbul/sbaa053. Epub 2020 Apr 15.

Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets.

Schizophrenia bulletin

Shiqiang Cheng, Yan Wen, Mei Ma, Lu Zhang, Li Liu, Xin Qi, Bolun Cheng, Chujun Liang, Ping Li, Om Prakash Kafle, Feng Zhang

Affiliations

  1. Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, P. R. China.

PMID: 32291453 PMCID: PMC7505178 DOI: 10.1093/schbul/sbaa053

Abstract

Psychiatric disorders are a group of complex psychological syndromes whose etiology remains unknown. Previous study suggested that various chemicals contributed to the development of psychiatric diseases through affecting gene expression. This study aims to systematically explore the potential relationships between 5 major psychiatric disorders and more than 11 000 chemicals. The genome-wide association studies (GWAS) datasets of attention deficiency/hyperactive disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depression disorder (MDD), and schizophrenia (SCZ) were driven from the Psychiatric GWAS Consortium and iPSYCH website. The chemicals related gene sets were obtained from the comparative toxicogenomics database (CTD). First, transcriptome-wide association studies (TWAS) were performed by FUSION to calculate the expression association testing statistics utilizing GWAS summary statistics of the 5 common psychiatric disorders. Chemical-related gene set enrichment analysis (GSEA) was then conducted to explore the relationships between chemicals and each of the psychiatric diseases. We observed several significant correlations between chemicals and each of the psychiatric disorders. We also detected common chemicals between every 4 of the 5 major psychiatric disorders, such as androgen antagonists for ADHD (P value = .0098), ASD (P value = .0330), BD (P value = .0238), and SCZ (P value = .0062), and imipramine for ADHD (P value = .0054), ASD (P value = .0386), MDD (P value = .0438), and SCZ (P value = .0008). Our study results provide new clues for revealing the roles of environmental chemicals in the development of psychiatric disorders.

© The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: [email protected].

Keywords: comparative toxicogenomics database; gene set enrichment analysis; genome-wide association study; psychiatric disorders; transcriptome-wide association study

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