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Fahmy UA, Badr-Eldin SM, Ahmed OAA, et al. Intranasal Niosomal . Pharmaceutics. 2020;12(6)doi: 10.3390/pharmaceutics12060485.
Fahmy, U. A., Badr-Eldin, S. M., Ahmed, O. A. A., Aldawsari, H. M., Tima, S., Asfour, H. Z., Al-Rabia, M. W., Negm, A. A., Sultan, M. H., Madkhali, O. A. A., & Alhakamy, N. A. (2020). Intranasal Niosomal . Pharmaceutics, 12(6), . https://doi.org/10.3390/pharmaceutics12060485
Fahmy, Usama A, et al. "Intranasal Niosomal ." Pharmaceutics vol. 12,6 (2020). doi: https://doi.org/10.3390/pharmaceutics12060485
Fahmy UA, Badr-Eldin SM, Ahmed OAA, Aldawsari HM, Tima S, Asfour HZ, Al-Rabia MW, Negm AA, Sultan MH, Madkhali OAA, Alhakamy NA. Intranasal Niosomal . Pharmaceutics. 2020 May 27;12(6). doi: 10.3390/pharmaceutics12060485. PMID: 32471119; PMCID: PMC7356232.
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Pharmaceutics. 2020 May 27;12(6). doi: 10.3390/pharmaceutics12060485.

Intranasal Niosomal .

Pharmaceutics

Usama A Fahmy, Shaimaa M Badr-Eldin, Osama A A Ahmed, Hibah M Aldawsari, Singkome Tima, Hani Z Asfour, Mohammed W Al-Rabia, Aya A Negm, Muhammad H Sultan, Osama A A Madkhali, Nabil A Alhakamy

Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  2. Advanced Drug Delivery Research Group, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  3. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
  4. Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  5. Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
  6. Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  7. Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig 44518, Egypt.
  8. Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
  9. King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

PMID: 32471119 PMCID: PMC7356232 DOI: 10.3390/pharmaceutics12060485

Abstract

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-pass effect, as well as its pH-dependent solubility, which could be an obstacle hindering the drug dissolution and absorption via mucosal barriers. Thus, this work aimed at overcoming the aforementioned drawbacks and promoting the nose-to-brain delivery of FLB via the formulation of an intra-nasal in situ niosomal gel. The Box-Behnken design was employed to study the impact of Span

Keywords: Box-Behnken; Span® 85; cholesterol; ex vivo permeation; flibanserin; gellan gum; niosomes; pharmacokinetics

References

  1. Adv Pharmacol Sci. 2018 Dec 11;2018:6847971 - PubMed
  2. Drug Dev Ind Pharm. 2010 Jul;36(7):751-61 - PubMed
  3. Drug Des Devel Ther. 2015 Mar 10;9:1427-35 - PubMed
  4. Drug Des Devel Ther. 2018 Oct 17;12:3501-3516 - PubMed
  5. Int J Pharm. 2020 May 30;582:119302 - PubMed
  6. Nanobiomedicine (Rij). 2018 Oct 11;5:1849543518805355 - PubMed
  7. Int J Nanomedicine. 2018 Oct 11;13:6325-6335 - PubMed
  8. Eur J Pharm Sci. 1999 Oct;9(1):99-105 - PubMed
  9. ACS Appl Mater Interfaces. 2018 Jun 6;10(22):19197-19207 - PubMed
  10. Recent Pat Drug Deliv Formul. 2016;10(2):156-64 - PubMed
  11. AAPS PharmSciTech. 2013 Sep;14(3):1072-82 - PubMed
  12. J Pharm Pharmacol. 1985 Apr;37(4):237-42 - PubMed
  13. Acta Pol Pharm. 2005 Sep-Oct;62(5):369-79 - PubMed
  14. Drug Deliv. 2016 Nov;23(9):3681-3695 - PubMed
  15. Drug Deliv. 2016 Sep;23(7):2144-2153 - PubMed
  16. Int J Pharm. 2015 May 15;485(1-2):235-43 - PubMed
  17. Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:789-97 - PubMed
  18. Pharmaceutics. 2019 Jan 29;11(2): - PubMed
  19. PLoS One. 2018 Apr 12;13(4):e0194179 - PubMed
  20. AAPS PharmSciTech. 2013 Jun;14(2):712-8 - PubMed
  21. Pharmaceuticals (Basel). 2019 Mar 29;12(2): - PubMed
  22. Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:1053-1062 - PubMed
  23. J Sex Med. 2016 Mar;13(3):338-49 - PubMed
  24. Eur J Pharm Biopharm. 2014 May;87(1):73-9 - PubMed
  25. Drug Des Devel Ther. 2016 Jan 12;10:205-15 - PubMed
  26. Int J Nanomedicine. 2018 Dec 18;14:33-43 - PubMed
  27. Biomed Pharmacother. 2017 Sep;93:255-266 - PubMed
  28. J Sex Med. 2010 May;7(5):1757-67 - PubMed
  29. Sex Med Rev. 2017 Oct;5(4):461-469 - PubMed
  30. Drug Deliv. 2008 May;15(4):219-25 - PubMed
  31. Pharmacol Ther. 2012 Jun;134(3):366-79 - PubMed
  32. Carbohydr Polym. 2012 Aug 1;89(4):1289-97 - PubMed
  33. Int J Nanomedicine. 2018 Feb 20;13:1059-1079 - PubMed
  34. Eur J Pharm Sci. 2013 Jan 23;48(1-2):195-201 - PubMed
  35. Drug Deliv. 2016 Jun;23(5):1536-49 - PubMed
  36. Ther Adv Chronic Dis. 2017 Jan;8(1):16-25 - PubMed
  37. Int J Nanomedicine. 2015 Feb 02;10:975-99 - PubMed
  38. Int J Pharm. 2005 Dec 8;306(1-2):71-82 - PubMed

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