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Lee C, So CH. The Impact of Perioperative Use of a Statin-Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching. Chonnam Med J. 2020;56(2):130-135doi: 10.4068/cmj.2020.56.2.130.
Lee, C., & So, C. H. (2020). The Impact of Perioperative Use of a Statin-Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching. Chonnam medical journal, 56(2), 130-135. https://doi.org/10.4068/cmj.2020.56.2.130
Lee, Cheol, and So, Cheol Hwan. "The Impact of Perioperative Use of a Statin-Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching." Chonnam medical journal vol. 56,2 (2020): 130-135. doi: https://doi.org/10.4068/cmj.2020.56.2.130
Lee C, So CH. The Impact of Perioperative Use of a Statin-Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching. Chonnam Med J. 2020 May;56(2):130-135. doi: 10.4068/cmj.2020.56.2.130. Epub 2020 May 25. PMID: 32509560; PMCID: PMC7250675.
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Chonnam Med J. 2020 May;56(2):130-135. doi: 10.4068/cmj.2020.56.2.130. Epub 2020 May 25.

The Impact of Perioperative Use of a Statin-Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching.

Chonnam medical journal

Cheol Lee, Cheol Hwan So

Affiliations

  1. Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan, Korea.
  2. Department of Pediatrics, Wonkwang University School of Medicine, Iksan, Korea.

PMID: 32509560 PMCID: PMC7250675 DOI: 10.4068/cmj.2020.56.2.130

Abstract

Both statins and magnesium are associated with NMDA receptors and anti-inflammatory effect. Peripheral NMDA receptors are known to be involved in inflammation-induced pain. This study aimed to investigate the impact of perioperative use of a statin-magnesium combination on opioid consumption in patients who underwent cardiac surgery. This was a retrospective study of 542 patients who underwent cardiac surgery. The patients were divided into two groups according to statin use: the statin-magnesium group (n=375) and the magnesium-only group (n=167). Patients in the magnesium-only group received only perioperative magnesium, but no statins, to prevent atrial fibrillation following cardiac surgery. After propensity-score matching, 228 patients (n=114 in each group) were analyzed to investigate opioid consumption, visual analogue scale (VAS) pain scores over a 72-h period, and pain outcomes according to the duration of statin treatment (<1 or ≥1 yr). The consumed opioid volume was significantly smaller in statin-magnesium group than the magnesium-only group, both before (p=0.010) and after matching (p=0.017). The statin-magnesium combination did not significantly reduce the VAS pain scores compared with magnesium alone. Although the statin-magnesium combination did not significantly reduce the pain intensity compared with magnesium alone, the combination therapy was effective in reducing opioid consumption after surgery.

© Chonnam Medical Journal, 2020.

Keywords: Anti-Arrhythmia Agents; Cardiac Surgical Procedures; Drug Interactions; Narcotics; Pain Management

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT: None declared.

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