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Scuteri D, Berliocchi L, Rombolà L, et al. Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice. Front Pharmacol. 2020;11:663doi: 10.3389/fphar.2020.00663.
Scuteri, D., Berliocchi, L., Rombolà, L., Morrone, L. A., Tonin, P., Bagetta, G., & Corasaniti, M. T. (2020). Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice. Frontiers in pharmacology, 11663. https://doi.org/10.3389/fphar.2020.00663
Scuteri, Damiana, et al. "Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice." Frontiers in pharmacology vol. 11 (2020): 663. doi: https://doi.org/10.3389/fphar.2020.00663
Scuteri D, Berliocchi L, Rombolà L, Morrone LA, Tonin P, Bagetta G, Corasaniti MT. Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice. Front Pharmacol. 2020 May 08;11:663. doi: 10.3389/fphar.2020.00663. eCollection 2020. PMID: 32457634; PMCID: PMC7227482.
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Front Pharmacol. 2020 May 08;11:663. doi: 10.3389/fphar.2020.00663. eCollection 2020.

Effects of Aging on Formalin-Induced Pain Behavior and Analgesic Activity of Gabapentin in C57BL/6 Mice.

Frontiers in pharmacology

Damiana Scuteri, Laura Berliocchi, Laura Rombolà, Luigi Antonio Morrone, Paolo Tonin, Giacinto Bagetta, Maria Tiziana Corasaniti

Affiliations

  1. Preclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, Cosenza, Italy.
  2. Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  3. Regional Center for Serious Brain Injuries, S. Anna Institute, Crotone, Italy.

PMID: 32457634 PMCID: PMC7227482 DOI: 10.3389/fphar.2020.00663

Abstract

Improved living conditions have induced an increase of lifespan often accompanied by comorbidities, responsible for pain, and by cognitive impairment and dementia, impairing communication capabilities. In most cases, the elderly do not receive pain relief because of underdiagnosis and of aging-induced changes of systems affecting nociceptive response. Unrelieved pain is involved in the development of behavioral symptoms, as agitation, representing a difficult challenge in this fragile population. Aged C57BL/6 mice and amyloid precursor protein (APP) mice display behavioral disturbances that mimic behavioral and psychological symptoms of dementia (BPSD). Therefore, this original study focuses on the influence of aging on nociception to provide insight into the occurrence of BPSD. We have investigated how aging can affect nociception after formalin administration and gabapentin effect in C57BL/6 mice, since it represents one of the treatments of choice for chronic neuropathic pain. Based on our results, changes of nociceptive behavior in response to an algogen stimulus occur during aging. Formalin-induced behavioral pattern in older C57BL/6 mice presents a temporal shift and an increase in the peak amplitudes. Our data show that the effectiveness of gabapentin is influenced by the age of the animal; though preliminary, the latter provide evidence upon which formalin test induced long-lasting mechanical allodynia might be a reliable as rapid and viable persistent pain model. The disclosed differences in effectiveness of gabapentin according to age can form the rational basis to deepen the study of pain treatment in the elderly.

Copyright © 2020 Scuteri, Berliocchi, Rombolà, Morrone, Tonin, Bagetta and Corasaniti.

Keywords: aging; behavioral and psychological symptoms of dementia; dementia; formalin test; gabapentin; pain

References

  1. J Nurs Scholarsh. 2005;37(2):134-40; discussion 140 - PubMed
  2. Curr Med Chem. 2019;26(20):3764-3774 - PubMed
  3. Neuropharmacology. 2013 Aug;71:204-15 - PubMed
  4. Ann Neurol. 2000 Sep;48(3):344-53 - PubMed
  5. Pain. 1977 Dec;4(2):161-74 - PubMed
  6. Psychol Aging. 1986 Sep;1(3):195-201 - PubMed
  7. Fitoterapia. 2018 Sep;129:20-24 - PubMed
  8. Eur J Pain. 2014 Nov;18(10):1490-500 - PubMed
  9. Neurobiol Aging. 1999 Nov-Dec;20(6):699-707 - PubMed
  10. J Am Geriatr Soc. 1987 Feb;35(2):101-8 - PubMed
  11. J Alzheimers Dis. 2014;41(2):499-513 - PubMed
  12. Neurosci Lett. 2017 Jun 9;651:151-158 - PubMed
  13. Geriatr Gerontol Int. 2020 Jan;20(1):78-84 - PubMed
  14. Evid Based Complement Alternat Med. 2017;2017:9416305 - PubMed
  15. Funct Neurol. 2017 Oct/Dec;22(4):229-230 - PubMed
  16. Pain. 1992 Oct;51(1):5-17 - PubMed
  17. Exp Neurol. 2013 May;243:67-73 - PubMed
  18. Pain Med. 2012 Apr;13 Suppl 2:S27-36 - PubMed
  19. Neurosci Lett. 2003 Mar 20;339(2):103-6 - PubMed
  20. Neurobiol Aging. 2017 Aug;56:100-107 - PubMed
  21. Neuroreport. 1994 Dec 20;5(18):2529-33 - PubMed
  22. Pain Physician. 2015 Sep-Oct;18(5):E863-76 - PubMed
  23. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11686-91 - PubMed
  24. Nurs Res. 1998 Jul-Aug;47(4):235-42 - PubMed
  25. Front Pharmacol. 2018 Feb 15;9:79 - PubMed
  26. Pain. 2015 Apr;156(4):675-83 - PubMed
  27. Eur J Pain. 2000;4(3):291-300 - PubMed
  28. BMJ. 2011 Jul 15;343:d4065 - PubMed
  29. J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):705-13 - PubMed
  30. Pain. 2000 Dec 15;89(1):89-96 - PubMed
  31. J Neurosci Methods. 1994 Jul;53(1):55-63 - PubMed
  32. Behav Processes. 2018 Dec;157:711-716 - PubMed
  33. Mol Pain. 2012 Aug 23;8:60 - PubMed
  34. Annu Rev Med. 2006;57:499-511 - PubMed
  35. J Gerontol. 1985 May;40(3):268-74 - PubMed
  36. Neural Regen Res. 2019 Aug;14(8):1445-1448 - PubMed
  37. J Pain. 2001 Feb;2(1):2-11 - PubMed
  38. J Pharmacol Exp Ther. 2002 Dec;303(3):1199-205 - PubMed
  39. Front Pharmacol. 2019 Apr 09;10:363 - PubMed
  40. Pain Med. 2012 Apr;13 Suppl 2:S44-50 - PubMed
  41. Lancet Neurol. 2003 Nov;2(11):677-86 - PubMed
  42. Exp Aging Res. 1981 Winter;7(4):427-51 - PubMed
  43. Methods Find Exp Clin Pharmacol. 1999 Sep;21(7):481-2 - PubMed
  44. Eur J Pharmacol. 2017 Feb 15;797:83-93 - PubMed
  45. Pain. 2010 Jul;150(1):153-60 - PubMed
  46. Gerontology. 2017;63(4):327-336 - PubMed
  47. Mol Pain. 2010 Nov 26;6:83 - PubMed
  48. Br J Pharmacol. 2002 Nov;137(6):813-20 - PubMed
  49. Clin Interv Aging. 2013;8:1471-82 - PubMed
  50. Annu Rev Pharmacol Toxicol. 1980;20:441-62 - PubMed
  51. Nature. 2012 Dec 6;492(7427):S2-3 - PubMed
  52. J Neurosci. 1998 Aug 1;18(15):5869-80 - PubMed
  53. Neural Regen Res. 2020 Jul;15(7):1340-1343 - PubMed
  54. J Neurosci. 2010 Jun 16;30(24):8203-13 - PubMed
  55. Arch Neurol. 2003 Mar;60(3):337-41 - PubMed
  56. Int Rev Neurobiol. 2002;53:387-409 - PubMed
  57. J Neuropathol Exp Neurol. 1997 Jan;56(1):86-93 - PubMed

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