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Alegre-Cortés E, Muriel-González A, Canales-Cortés S, et al. Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel). 2020;9(6)doi: 10.3390/antiox9060524.
Alegre-Cortés, E., Muriel-González, A., Canales-Cortés, S., Uribe-Carretero, E., Martínez-Chacón, G., Aiastui, A., López de Munain, A., Niso-Santano, M., Gonzalez-Polo, R. A., Fuentes, J. M., & Yakhine-Diop, S. M. S. (2020). Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel, Switzerland), 9(6), . https://doi.org/10.3390/antiox9060524
Alegre-Cortés, Eva, et al. "Toxicity of Necrostatin-1 in Parkinson's Disease Models." Antioxidants (Basel, Switzerland) vol. 9,6 (2020). doi: https://doi.org/10.3390/antiox9060524
Alegre-Cortés E, Muriel-González A, Canales-Cortés S, Uribe-Carretero E, Martínez-Chacón G, Aiastui A, López de Munain A, Niso-Santano M, Gonzalez-Polo RA, Fuentes JM, Yakhine-Diop SMS. Toxicity of Necrostatin-1 in Parkinson's Disease Models. Antioxidants (Basel). 2020 Jun 15;9(6). doi: 10.3390/antiox9060524. PMID: 32549347; PMCID: PMC7346148.
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Antioxidants (Basel). 2020 Jun 15;9(6). doi: 10.3390/antiox9060524.

Toxicity of Necrostatin-1 in Parkinson's Disease Models.

Antioxidants (Basel, Switzerland)

Eva Alegre-Cortés, Alicia Muriel-González, Saray Canales-Cortés, Elisabet Uribe-Carretero, Guadalupe Martínez-Chacón, Ana Aiastui, Adolfo López de Munain, Mireia Niso-Santano, Rosa A Gonzalez-Polo, José M Fuentes, Sokhna M S Yakhine-Diop

Affiliations

  1. Depto. Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura Avda de la Universidad s/n, 10003 Cáceres, Spain.
  2. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 28049 Madrid, Spain.
  3. Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain.
  4. Cell Culture Plataform, Donostia University Hospital, 20014 San Sebastián, Spain.
  5. Neuroscience Area of Biodonostia Health Research Institute, Donostia University Hospital, 20014 San Sebastián, Spain.
  6. Department of Neurology, Donostia University Hospital, 20014 San Sebastian, Spain.
  7. Ilundain Fundazioa, 20014 San Sebastian, Spain.
  8. Department of Neurosciences, University of the Basque Country UPV-EHU, 20014 San Sebastián, Spain.

PMID: 32549347 PMCID: PMC7346148 DOI: 10.3390/antiox9060524

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. This neuronal loss, inherent to age, is related to exposure to environmental toxins and/or a genetic predisposition. PD-induced cell death has been studied thoroughly, but its characterization remains elusive. To date, several types of cell death, including apoptosis, autophagy-induced cell death, and necrosis, have been implicated in PD progression. In this study, we evaluated necroptosis, which is a programmed type of necrosis, in primary fibroblasts from PD patients with and without the G2019S

Keywords: MLKL; RIP; mitochondria; mitophagy; necroptosis; rotenone

Conflict of interest statement

The authors declare no conflict of interest.

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