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Schmidt MA, Engelhorn T, Lang S, et al. DSC Brain Perfusion Using Advanced Deconvolution Models in the Diagnostic Work-up of Dementia and Mild Cognitive Impairment: A Semiquantitative Comparison with HMPAO-SPECT-Brain Perfusion. J Clin Med. 2020;9(6)doi: 10.3390/jcm9061800.
Schmidt, M. A., Engelhorn, T., Lang, S., Luecking, H., Hoelter, P., Fröhlich, K., Ritt, P., Maler, J. M., Kuwert, T., Kornhuber, J., & Doerfler, A. (2020). DSC Brain Perfusion Using Advanced Deconvolution Models in the Diagnostic Work-up of Dementia and Mild Cognitive Impairment: A Semiquantitative Comparison with HMPAO-SPECT-Brain Perfusion. Journal of clinical medicine, 9(6), . https://doi.org/10.3390/jcm9061800
Schmidt, Manuel A, et al. "DSC Brain Perfusion Using Advanced Deconvolution Models in the Diagnostic Work-up of Dementia and Mild Cognitive Impairment: A Semiquantitative Comparison with HMPAO-SPECT-Brain Perfusion." Journal of clinical medicine vol. 9,6 (2020). doi: https://doi.org/10.3390/jcm9061800
Schmidt MA, Engelhorn T, Lang S, Luecking H, Hoelter P, Fröhlich K, Ritt P, Maler JM, Kuwert T, Kornhuber J, Doerfler A. DSC Brain Perfusion Using Advanced Deconvolution Models in the Diagnostic Work-up of Dementia and Mild Cognitive Impairment: A Semiquantitative Comparison with HMPAO-SPECT-Brain Perfusion. J Clin Med. 2020 Jun 09;9(6). doi: 10.3390/jcm9061800. PMID: 32527014; PMCID: PMC7356248.
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J Clin Med. 2020 Jun 09;9(6). doi: 10.3390/jcm9061800.

DSC Brain Perfusion Using Advanced Deconvolution Models in the Diagnostic Work-up of Dementia and Mild Cognitive Impairment: A Semiquantitative Comparison with HMPAO-SPECT-Brain Perfusion.

Journal of clinical medicine

Manuel A Schmidt, Tobias Engelhorn, Stefan Lang, Hannes Luecking, Philip Hoelter, Kilian Fröhlich, Philipp Ritt, Juan Manuel Maler, Torsten Kuwert, Johannes Kornhuber, Arnd Doerfler

Affiliations

  1. Departments of Neuroradiology, Friedrich-Alexander-University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
  2. Departments of Neurology, Friedrich-Alexander-University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
  3. Department of Nuclear Medicine, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany.
  4. Departments of Psychiatry, Friedrich-Alexander-University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.

PMID: 32527014 PMCID: PMC7356248 DOI: 10.3390/jcm9061800

Abstract

BACKGROUND: SPECT (single-photon emission-computed tomography) is used for the detection of hypoperfusion in cognitive impairment and dementia but is not widely available and related to radiation dose exposure. We compared the performance of DSC (dynamic susceptibility contrast) perfusion using semi- and fully adaptive deconvolution models to HMPAO-SPECT (99mTc-hexamethylpropyleneamine oxime-SPECT).

MATERIAL AND METHODS: Twenty-seven patients with dementia of different subtypes including frontotemporal dementia (FTD) and mild cognitive impairment (MCI) received a multimodal diagnostic work-up including DSC perfusion at a clinical 3T high-field scanner and HMPAO-SPECT. Nineteen healthy control individuals received DSC perfusion. For calculation of the hemodynamic parameter maps, oscillation-index standard truncated singular value decomposition (oSVD, semi-adaptive) as well as Bayesian parameter estimation (BAY, fully adaptive) were performed.

RESULTS: Patients showed decreased cortical perfusion in the left frontal lobe compared to controls (relative cerebral blood volume corrected, rBVc: 0.37 vs 0.27,

CONCLUSION: Advanced deconvolution DSC can reliably detect pathological perfusion alterations in FTD and MCI. Hence, this widely accessible technique has the potential to improve the diagnosis of dementia and MCI as part of an interdisciplinary multimodal imaging work-up. Advances in knowledge: Advanced DSC perfusion has a high potential in the work-up of suspected dementia and correlates with SPECT brain perfusion results in dementia and MCI.

Keywords: DSC (dynamic susceptibility contrast) perfusion; SPECT (single-photon emission-computed tomography); brain perfusion; dementia

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