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Wu J, Ning P, Gao R, et al. Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions. Adv Sci (Weinh). 2020;7(12):1902933doi: 10.1002/advs.201902933.
Wu, J., Ning, P., Gao, R., Feng, Q., Shen, Y., Zhang, Y., Li, Y., Xu, C., Qin, Y., Plaza, G. R., Bai, Q., Fan, X., Li, Z., Han, Y., Lesniak, M. S., Fan, H., & Cheng, Y. (2020). Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(12), 1902933. https://doi.org/10.1002/advs.201902933
Wu, Jiaojiao, et al. "Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 7,12 (2020): 1902933. doi: https://doi.org/10.1002/advs.201902933
Wu J, Ning P, Gao R, Feng Q, Shen Y, Zhang Y, Li Y, Xu C, Qin Y, Plaza GR, Bai Q, Fan X, Li Z, Han Y, Lesniak MS, Fan H, Cheng Y. Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions. Adv Sci (Weinh). 2020 May 09;7(12):1902933. doi: 10.1002/advs.201902933. eCollection 2020 Jun. PMID: 32596106; PMCID: PMC7312334.
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Adv Sci (Weinh). 2020 May 09;7(12):1902933. doi: 10.1002/advs.201902933. eCollection 2020 Jun.

Programmable ROS-Mediated Cancer Therapy via Magneto-Inductions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Jiaojiao Wu, Peng Ning, Rui Gao, Qishuai Feng, Yajing Shen, Yifan Zhang, Yingze Li, Chang Xu, Yao Qin, Gustavo R Plaza, Qianwen Bai, Xing Fan, Zhenguang Li, Yu Han, Maciej S Lesniak, Haiming Fan, Yu Cheng

Affiliations

  1. Institute for Regenerative Medicine, Institute for Translational Nanomedicine, Shanghai East Hospital Tongji University School of Medicine 1800 Yuntai Road Shanghai 200123 China.
  2. Collaborative Innovation Center for Brain Science Tongji University Shanghai 200092 China.
  3. College of Chemistry and Materials Science Northwest University Xi'an 710127 China.
  4. Center for Biomedical Technology Universidad Politécnica de Madrid Pozuelo de Alarcón 28223 Spain.
  5. Feinberg School of Medicine Northwestern University 676 North Saint Clair Street, Suite 2210 Chicago IL 60611 USA.

PMID: 32596106 PMCID: PMC7312334 DOI: 10.1002/advs.201902933

Abstract

Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep-tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise cancer treatment. Here, a mechanical-thermal induction therapy (MTIT) strategy is developed for a programmable increase of ROS levels in cancer cells via assembly of magnetic nanocubes integrated with alternating magnetic fields. The magneto-based mechanical and thermal stimuli can disrupt the lysosomes, which sequentially induce the dysfunction of mitochondria. Importantly, intracellular ROS concentrations are responsive to the magneto-triggers and play a key role for synergistic cancer treatment. In vivo experiments reveal the effectiveness of MTIT for efficient eradication of glioma and breast cancer. By remote control of the force and heat using magnetic nanocubes, MTIT is a promising physical approach to trigger the biochemical responses for precise cancer treatment.

© 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: cancer treatment; magnetic fields; magnetic nanoparticles; reactive oxygen species; synergistic effects

Conflict of interest statement

The authors declare no conflict of interest.

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