Front Cell Dev Biol. 2020 Jun 03;8:431. doi: 10.3389/fcell.2020.00431. eCollection 2020.
Interplay Between Lipid Metabolism and Autophagy.
Frontiers in cell and developmental biology
Yangchun Xie, Jingbo Li, Rui Kang, Daolin Tang
Affiliations
Affiliations
- Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.
- Department of Surgery, UT Southwestern Medical Center, Dallas, TX, United States.
PMID: 32582708
PMCID: PMC7283384 DOI: 10.3389/fcell.2020.00431
Abstract
Autophagy is a self-eating process of using lysosomes to degrade macromolecular substances (e.g., proteins and organelles) that are damaged, degenerated, or aging. Lipid metabolism is the synthesis and degradation of lipids (e.g., triglycerides, steroids, and phospholipids) to generate energy or produce the structural components of cell membranes. There is a complex interplay between lipid metabolism (e.g., digestion, absorption, catabolism, biosynthesis, and peroxidation) and autophagy machinery, leading to the modulation of cell homeostasis, including cell survival and death. In particular, lipid metabolism is involved in the formation of autophagic membrane structures (e.g., phagophores and autophagosomes) during stress. Moreover, autophagy, especially selective autophagy (e.g., lipophagy, ferritinophagy, clockophagy, and mitophagy), promotes lipid catabolism or lipid peroxidation-induced ferroptosis through the degradation of various substances within the cell. A better understanding of the mechanisms of autophagy and possible links to lipid metabolism will undoubtedly promote potential treatments for a variety of diseases.
Copyright © 2020 Xie, Li, Kang and Tang.
Keywords: autophagy; clockophagy; disease; ferritinophagy; lipid; lipophagy; metabolism; mitophagy
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