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Khatoon E, Banik K, Harsha C, et al. Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Semin Cancer Biol. 2020;doi: 10.1016/j.semcancer.2020.06.014.
Khatoon, E., Banik, K., Harsha, C., Sailo, B. L., Thakur, K. K., Khwairakpam, A. D., Vikkurthi, R., Devi, T. B., Gupta, S. C., & Kunnumakkara, A. B. (2020). Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Seminars in cancer biology, . https://doi.org/10.1016/j.semcancer.2020.06.014
Khatoon, Elina, et al. "Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives." Seminars in cancer biology vol. (2020). doi: https://doi.org/10.1016/j.semcancer.2020.06.014
Khatoon E, Banik K, Harsha C, Sailo BL, Thakur KK, Khwairakpam AD, Vikkurthi R, Devi TB, Gupta SC, Kunnumakkara AB. Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Semin Cancer Biol. 2020 Jun 28; doi: 10.1016/j.semcancer.2020.06.014. Epub 2020 Jun 28. PMID: 32610149.
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Semin Cancer Biol. 2020 Jun 28; doi: 10.1016/j.semcancer.2020.06.014. Epub 2020 Jun 28.

Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives.

Seminars in cancer biology

Elina Khatoon, Kishore Banik, Choudhary Harsha, Bethsebie Lalduhsaki Sailo, Krishan Kumar Thakur, Amrita Devi Khwairakpam, Rajesh Vikkurthi, Thengujam Babita Devi, Subash C Gupta, Ajaikumar B Kunnumakkara

Affiliations

  1. Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, 781 039, Assam, India; DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Indian Institute of Technology (IIT) Guwahati, Guwahati, 781 039, Assam, India.
  2. Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221 005, Uttar Pradesh, India.
  3. Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, 781 039, Assam, India; DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Indian Institute of Technology (IIT) Guwahati, Guwahati, 781 039, Assam, India. Electronic address: [email protected].

PMID: 32610149 DOI: 10.1016/j.semcancer.2020.06.014

Abstract

Despite significant advancements made in the treatment of cancer during the past several decades, it remains one of the leading causes of death worldwide killing approximately 9.6 million people annually. The major challenge for therapeutic success is the development of chemoresistance in cancer cells against conventional chemotherapeutic agents via modulation of numerous survival and oncogenic signaling pathways. Therefore, sensitization of cancer cells to conventional drugs using multitargeted agents that suppress the survival and oncogenic pathways, in single or in combination, is an emerging strategy to overcome drug-resistance. During the last couple of decades, phytochemicals such as curcumin, resveratrol, tocotrienol and quercetin have emerged as potential chemosensitizing agents in cancer cells due to their less toxic and multitargeted properties. Numerous preclinical and clinical studies enumerated their potential to prevent drug resistance and sensitize cancer cells to chemotherapeutic agents by modulating several genes/proteins or pathways that regulate the key factors during the growth and progression of tumors such as inhibition of anti-apoptotic proteins, activation of pro-apoptotic proteins, reduced expression of different transcription factors, chemokines, enzymes, cell adhesion molecules, protein tyrosine kinases and cell cycle regulators. Therefore, natural chemosensitizing agents will have a special place in cancer treatment in the near future. This comprehensive review summarizes data obtained from various in vitro, in vivo and clinical studies to provide a new perspective for the application of agents obtained from "Mother Nature" as potential chemosensitizers for further cancer drug research and development.

Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords: Cancer; Chemoresistance; Chemosensitization; Combination therapy; Multitargeted agents; Phytochemicals

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