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Showing 1 to 12 of 38 entries
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Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer.

Molecular biomedicine

Girisa S, Henamayee S, Parama D, Rana V, Dutta U, Kunnumakkara AB.
PMID: 35006466
Mol Biomed. 2021 Jul 10;2(1):21. doi: 10.1186/s43556-021-00035-2.

Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell. One of those alterations associated with cancer corresponds to differential expression of Farnesoid X receptor (FXR), a nuclear receptor regulating bile, cholesterol...

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Girisa S, Henamayee S, Parama D, et al. Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer. Mol Biomed. 2021;2(1):21doi: 10.1186/s43556-021-00035-2.
Girisa, S., Henamayee, S., Parama, D., Rana, V., Dutta, U., & Kunnumakkara, A. B. (2021). Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer. Molecular biomedicine, 2(1), 21. https://doi.org/10.1186/s43556-021-00035-2
Girisa, Sosmitha, et al. "Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer." Molecular biomedicine vol. 2,1 (2021): 21. doi: https://doi.org/10.1186/s43556-021-00035-2
Girisa S, Henamayee S, Parama D, Rana V, Dutta U, Kunnumakkara AB. Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer. Mol Biomed. 2021 Jul 10;2(1):21. doi: 10.1186/s43556-021-00035-2. PMID: 35006466.
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Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis.

Journal of cellular physiology

Thakur KK, Kumar A, Banik K, Verma E, Khatoon E, Harsha C, Sethi G, Gupta SC, Kunnumakkara AB.
PMID: 34105151
J Cell Physiol. 2021 Dec;236(12):7938-7965. doi: 10.1002/jcp.30463. Epub 2021 Jun 08.

In recent years, triple-negative breast cancer (TNBC) has emerged as the most aggressive subtype of breast cancer and is usually associated with increased mortality worldwide. The severity of TNBC is primarily observed in younger women, with cases ranging from...

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Thakur KK, Kumar A, Banik K, et al. Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis. J Cell Physiol. 2021;236(12):7938-7965doi: 10.1002/jcp.30463.
Thakur, K. K., Kumar, A., Banik, K., Verma, E., Khatoon, E., Harsha, C., Sethi, G., Gupta, S. C., & Kunnumakkara, A. B. (2021). Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis. Journal of cellular physiology, 236(12), 7938-7965. https://doi.org/10.1002/jcp.30463
Thakur, Krishan K, et al. "Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis." Journal of cellular physiology vol. 236,12 (2021): 7938-7965. doi: https://doi.org/10.1002/jcp.30463
Thakur KK, Kumar A, Banik K, Verma E, Khatoon E, Harsha C, Sethi G, Gupta SC, Kunnumakkara AB. Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis. J Cell Physiol. 2021 Dec;236(12):7938-7965. doi: 10.1002/jcp.30463. Epub 2021 Jun 08. PMID: 34105151.
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Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases.

Journal of biochemical and molecular toxicology

Devi Daimary U, Girisa S, Parama D, Verma E, Kumar A, Kunnumakkara AB.
PMID: 34842329
J Biochem Mol Toxicol. 2021 Nov 29;e22950. doi: 10.1002/jbt.22950. Epub 2021 Nov 29.

Chronic diseases are a serious health concern worldwide, especially in the elderly population. Most chronic diseases like cancer, cardiovascular ailments, neurodegenerative disorders, and autoimmune diseases are caused due to the abnormal functioning of multiple signaling pathways that give rise...

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Devi Daimary U, Girisa S, Parama D, et al. Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases. J Biochem Mol Toxicol. 2021;e22950doi: 10.1002/jbt.22950.
Devi Daimary, U., Girisa, S., Parama, D., Verma, E., Kumar, A., & Kunnumakkara, A. B. (2021). Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases. Journal of biochemical and molecular toxicology, e22950. https://doi.org/10.1002/jbt.22950
Devi Daimary, Uzini, et al. "Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases." Journal of biochemical and molecular toxicology vol. (2021): e22950. doi: https://doi.org/10.1002/jbt.22950
Devi Daimary U, Girisa S, Parama D, Verma E, Kumar A, Kunnumakkara AB. Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases. J Biochem Mol Toxicol. 2021 Nov 29;e22950. doi: 10.1002/jbt.22950. Epub 2021 Nov 29. PMID: 34842329.
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Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment.

Frontiers in oncology

Buhrmann C, Kunnumakkara AB, Kumar A, Samec M, Kubatka P, Aggarwal BB, Shakibaei M.
PMID: 34660256
Front Oncol. 2021 Sep 29;11:650603. doi: 10.3389/fonc.2021.650603. eCollection 2021.

BACKGROUND: Tumor microenvironment (TME) provides the essential prerequisite niche for promoting cancer progression and metastasis. Calebin A, a component of METHODS: 3D-alginate tumor cultures (HCT116 cells) in the multicellular proinflammatory TME (fibroblast cells/T lymphocytes), tumor necrosis factor beta (TNF-β)-TME...

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Buhrmann C, Kunnumakkara AB, Kumar A, et al. Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment. Front Oncol. 2021;11:650603doi: 10.3389/fonc.2021.650603.
Buhrmann, C., Kunnumakkara, A. B., Kumar, A., Samec, M., Kubatka, P., Aggarwal, B. B., & Shakibaei, M. (2021). Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment. Frontiers in oncology, 11650603. https://doi.org/10.3389/fonc.2021.650603
Buhrmann, Constanze, et al. "Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment." Frontiers in oncology vol. 11 (2021): 650603. doi: https://doi.org/10.3389/fonc.2021.650603
Buhrmann C, Kunnumakkara AB, Kumar A, Samec M, Kubatka P, Aggarwal BB, Shakibaei M. Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment. Front Oncol. 2021 Sep 29;11:650603. doi: 10.3389/fonc.2021.650603. eCollection 2021. PMID: 34660256; PMCID: PMC8511772.
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Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases.

Phytotherapy research : PTR

Kumar A, Harsha C, Parama D, Girisa S, Daimary UD, Mao X, Kunnumakkara AB.
PMID: 34498308
Phytother Res. 2021 Sep 08; doi: 10.1002/ptr.7264. Epub 2021 Sep 08.

The last decade has seen an unprecedented rise in the prevalence of chronic diseases worldwide. Different mono-targeted approaches have been devised to treat these multigenic diseases, still most of them suffer from limited success due to the off-target debilitating...

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Kumar A, Harsha C, Parama D, et al. Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases. Phytother Res. 2021;doi: 10.1002/ptr.7264.
Kumar, A., Harsha, C., Parama, D., Girisa, S., Daimary, U. D., Mao, X., & Kunnumakkara, A. B. (2021). Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases. Phytotherapy research : PTR, . https://doi.org/10.1002/ptr.7264
Kumar, Aviral, et al. "Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases." Phytotherapy research : PTR vol. (2021). doi: https://doi.org/10.1002/ptr.7264
Kumar A, Harsha C, Parama D, Girisa S, Daimary UD, Mao X, Kunnumakkara AB. Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases. Phytother Res. 2021 Sep 08; doi: 10.1002/ptr.7264. Epub 2021 Sep 08. PMID: 34498308.
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Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from .

ACS pharmacology & translational science

Aswathy M, Banik K, Parama D, Sasikumar P, Harsha C, Joseph AG, Sherin DR, Thanathu MK, Kunnumakkara AB, Vasu RK.
PMID: 33860206
ACS Pharmacol Transl Sci. 2021 Mar 09;4(2):834-847. doi: 10.1021/acsptsci.1c00011. eCollection 2021 Apr 09.

Triterpenoids are ubiquitously distributed secondary metabolites, primarily scrutinized as a source of medication and preventive measures for various chronic diseases. The ease of isolation and excellent pharmacological properties of triterpenoids are notable reasons behind the exponential rise of extensive...

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Aswathy M, Banik K, Parama D, et al. Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from . ACS Pharmacol Transl Sci. 2021;4(2):834-847doi: 10.1021/acsptsci.1c00011.
Aswathy, M., Banik, K., Parama, D., Sasikumar, P., Harsha, C., Joseph, A. G., Sherin, D. R., Thanathu, M. K., Kunnumakkara, A. B., & Vasu, R. K. (2021). Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from . ACS pharmacology & translational science, 4(2), 834-847. https://doi.org/10.1021/acsptsci.1c00011
Aswathy, Maniyamma, et al. "Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from ." ACS pharmacology & translational science vol. 4,2 (2021): 834-847. doi: https://doi.org/10.1021/acsptsci.1c00011
Aswathy M, Banik K, Parama D, Sasikumar P, Harsha C, Joseph AG, Sherin DR, Thanathu MK, Kunnumakkara AB, Vasu RK. Exploring the Cytotoxic Effects of the Extracts and Bioactive Triterpenoids from . ACS Pharmacol Transl Sci. 2021 Mar 09;4(2):834-847. doi: 10.1021/acsptsci.1c00011. eCollection 2021 Apr 09. PMID: 33860206; PMCID: PMC8033758.
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Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives.

Seminars in cancer biology

Khatoon E, Banik K, Harsha C, Sailo BL, Thakur KK, Khwairakpam AD, Vikkurthi R, Devi TB, Gupta SC, Kunnumakkara AB.
PMID: 32610149
Semin Cancer Biol. 2020 Jun 28; doi: 10.1016/j.semcancer.2020.06.014. Epub 2020 Jun 28.

Despite significant advancements made in the treatment of cancer during the past several decades, it remains one of the leading causes of death worldwide killing approximately 9.6 million people annually. The major challenge for therapeutic success is the development...

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Khatoon E, Banik K, Harsha C, et al. Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Semin Cancer Biol. 2020;doi: 10.1016/j.semcancer.2020.06.014.
Khatoon, E., Banik, K., Harsha, C., Sailo, B. L., Thakur, K. K., Khwairakpam, A. D., Vikkurthi, R., Devi, T. B., Gupta, S. C., & Kunnumakkara, A. B. (2020). Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Seminars in cancer biology, . https://doi.org/10.1016/j.semcancer.2020.06.014
Khatoon, Elina, et al. "Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives." Seminars in cancer biology vol. (2020). doi: https://doi.org/10.1016/j.semcancer.2020.06.014
Khatoon E, Banik K, Harsha C, Sailo BL, Thakur KK, Khwairakpam AD, Vikkurthi R, Devi TB, Gupta SC, Kunnumakkara AB. Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives. Semin Cancer Biol. 2020 Jun 28; doi: 10.1016/j.semcancer.2020.06.014. Epub 2020 Jun 28. PMID: 32610149.
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Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds.

Anti-cancer agents in medicinal chemistry

Mehta KA, Patel KA, Kunnumakkara AB, Patel PS.
PMID: 33238851
Anticancer Agents Med Chem. 2021;21(13):1717-1723. doi: 10.2174/1871520620999201124213259.

BACKGROUND: Aberrant glycosylation has been recently considered as a major hallmark of cancer. Furthermore, we have reported that aberrant glycosylation, mainly sialylation and fucosylation, plays a major role in oral cancer progression and metastasis.OBJECTIVE: In the present study, we...

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Mehta KA, Patel KA, Kunnumakkara AB, et al. Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds. Anticancer Agents Med Chem. 2021;21(13):1717-1723doi: 10.2174/1871520620999201124213259.
Mehta, K. A., Patel, K. A., Kunnumakkara, A. B., & Patel, P. S. (2021). Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds. Anti-cancer agents in medicinal chemistry, 21(13), 1717-1723. https://doi.org/10.2174/1871520620999201124213259
Mehta, Kruti A, et al. "Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds." Anti-cancer agents in medicinal chemistry vol. 21,13 (2021): 1717-1723. doi: https://doi.org/10.2174/1871520620999201124213259
Mehta KA, Patel KA, Kunnumakkara AB, Patel PS. Curbing the Deregulation of Glycosylation in Tongue Carcinoma Cells with Natural Compounds. Anticancer Agents Med Chem. 2021;21(13):1717-1723. doi: 10.2174/1871520620999201124213259. PMID: 33238851.
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Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases.

Current research in pharmacology and drug discovery

Daimary UD, Parama D, Rana V, Banik K, Kumar A, Harsha C, Kunnumakkara AB.
PMID: 34909644
Curr Res Pharmacol Drug Discov. 2020 Dec 10;2:100008. doi: 10.1016/j.crphar.2020.100008. eCollection 2021.

Although chronic diseases are often caused by the perturbations in multiple cellular components involved in different biological processes, most of the approved therapeutics target a single gene/protein/pathway which makes them not as efficient as they are anticipated and are...

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Daimary UD, Parama D, Rana V, et al. Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases. Curr Res Pharmacol Drug Discov. 2020;2:100008doi: 10.1016/j.crphar.2020.100008.
Daimary, U. D., Parama, D., Rana, V., Banik, K., Kumar, A., Harsha, C., & Kunnumakkara, A. B. (2021). Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases. Current research in pharmacology and drug discovery, 2100008. https://doi.org/10.1016/j.crphar.2020.100008
Daimary, Uzini Devi, et al. "Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases." Current research in pharmacology and drug discovery vol. 2 (2021): 100008. doi: https://doi.org/10.1016/j.crphar.2020.100008
Daimary UD, Parama D, Rana V, Banik K, Kumar A, Harsha C, Kunnumakkara AB. Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases. Curr Res Pharmacol Drug Discov. 2020 Dec 10;2:100008. doi: 10.1016/j.crphar.2020.100008. eCollection 2021. PMID: 34909644; PMCID: PMC8663944.
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Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway.

Cancers

Arora L, Mohan CD, Yang MH, Rangappa S, Deivasigamani A, Kumar AP, Kunnumakkara AB, Garg M, Chinnathambi A, Alharbi SA, Alahmadi TA, Rangappa KS, Hui KM, Sethi G, Ahn KS.
PMID: 34771643
Cancers (Basel). 2021 Oct 31;13(21). doi: 10.3390/cancers13215479.

STAT3 is an oncogenic transcription factor that controls the expression of genes associated with oncogenesis and malignant progression. Persistent activation of STAT3 is observed in human malignancies, including hepatocellular carcinoma (HCC) and multiple myeloma (MM). Here, we have investigated...

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Arora L, Mohan CD, Yang MH, et al. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers (Basel). 2021;13(21)doi: 10.3390/cancers13215479.
Arora, L., Mohan, C. D., Yang, M. H., Rangappa, S., Deivasigamani, A., Kumar, A. P., Kunnumakkara, A. B., Garg, M., Chinnathambi, A., Alharbi, S. A., Alahmadi, T. A., Rangappa, K. S., Hui, K. M., Sethi, G., & Ahn, K. S. (2021). Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers, 13(21), . https://doi.org/10.3390/cancers13215479
Arora, Loukik, et al. "Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway." Cancers vol. 13,21 (2021). doi: https://doi.org/10.3390/cancers13215479
Arora L, Mohan CD, Yang MH, Rangappa S, Deivasigamani A, Kumar AP, Kunnumakkara AB, Garg M, Chinnathambi A, Alharbi SA, Alahmadi TA, Rangappa KS, Hui KM, Sethi G, Ahn KS. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers (Basel). 2021 Oct 31;13(21). doi: 10.3390/cancers13215479. PMID: 34771643; PMCID: PMC8582575.
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Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells.

Biomedicines

Buhrmann C, Shayan P, Banik K, Kunnumakkara AB, Kubatka P, Koklesova L, Shakibaei M, Su JQ.
PMID: 32708030
Biomedicines. 2020 Jul 22;8(8). doi: 10.3390/biomedicines8080236.

Increasing lines of evidence suggest that chronic inflammation mediates most chronic diseases, including cancer. The transcription factor, NF-κB, has been shown to be a major regulator of inflammation and metastasis in tumor cells. Therefore, compounds or any natural agents...

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Buhrmann C, Shayan P, Banik K, et al. Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells. Biomedicines. 2020;8(8)doi: 10.3390/biomedicines8080236.
Buhrmann, C., Shayan, P., Banik, K., Kunnumakkara, A. B., Kubatka, P., Koklesova, L., Shakibaei, M., & Su, J. Q. (2020). Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells. Biomedicines, 8(8), . https://doi.org/10.3390/biomedicines8080236
Buhrmann, Constanze, et al. "Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells." Biomedicines vol. 8,8 (2020). doi: https://doi.org/10.3390/biomedicines8080236
Buhrmann C, Shayan P, Banik K, Kunnumakkara AB, Kubatka P, Koklesova L, Shakibaei M, Su JQ. Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells. Biomedicines. 2020 Jul 22;8(8). doi: 10.3390/biomedicines8080236. PMID: 32708030; PMCID: PMC7460490.
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Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.

Frontiers in pharmacology

Kunnumakkara AB, Banik K, Bordoloi D, Harsha C, Sailo BL, Padmavathi G, Roy NK, Gupta SC, Aggarwal BB.
PMID: 30127736
Front Pharmacol. 2018 Aug 06;9:686. doi: 10.3389/fphar.2018.00686. eCollection 2018.

Extensive research during last 2 decades has revealed that most drugs discovered today, although costs billions of dollars for discovery, and yet they are highly ineffective in their clinical response. For instance, the European Medicines Agency has approved 68...

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Kunnumakkara AB, Banik K, Bordoloi D, et al. Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Front Pharmacol. 2018;9:686doi: 10.3389/fphar.2018.00686.
Kunnumakkara, A. B., Banik, K., Bordoloi, D., Harsha, C., Sailo, B. L., Padmavathi, G., Roy, N. K., Gupta, S. C., & Aggarwal, B. B. (2018). Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Frontiers in pharmacology, 9686. https://doi.org/10.3389/fphar.2018.00686
Kunnumakkara, Ajaikumar B, et al. "Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases." Frontiers in pharmacology vol. 9 (2018): 686. doi: https://doi.org/10.3389/fphar.2018.00686
Kunnumakkara AB, Banik K, Bordoloi D, Harsha C, Sailo BL, Padmavathi G, Roy NK, Gupta SC, Aggarwal BB. Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Front Pharmacol. 2018 Aug 06;9:686. doi: 10.3389/fphar.2018.00686. eCollection 2018. PMID: 30127736; PMCID: PMC6087759.
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