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Thijssen EGJ, van Gestel NAP, Bevers R, et al. Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations. Front Bioeng Biotechnol. 2020;8:634doi: 10.3389/fbioe.2020.00634.
Thijssen, E. G. J., van Gestel, N. A. P., Bevers, R., Hofmann, S., Geurts, J., van Loo, I. H. M., & Arts, J. J. (2020). Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations. Frontiers in bioengineering and biotechnology, 8634. https://doi.org/10.3389/fbioe.2020.00634
Thijssen, Eline G J, et al. "Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations." Frontiers in bioengineering and biotechnology vol. 8 (2020): 634. doi: https://doi.org/10.3389/fbioe.2020.00634
Thijssen EGJ, van Gestel NAP, Bevers R, Hofmann S, Geurts J, van Loo IHM, Arts JJ. Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations. Front Bioeng Biotechnol. 2020 Jun 26;8:634. doi: 10.3389/fbioe.2020.00634. eCollection 2020. PMID: 32676498; PMCID: PMC7333246.
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Front Bioeng Biotechnol. 2020 Jun 26;8:634. doi: 10.3389/fbioe.2020.00634. eCollection 2020.

Assessment of Growth Reduction of Five Clinical Pathogens by Injectable S53P4 Bioactive Glass Material Formulations.

Frontiers in bioengineering and biotechnology

Eline G J Thijssen, Nicole A P van Gestel, Raymond Bevers, Sandra Hofmann, Jan Geurts, Inge H M van Loo, J J Arts

Affiliations

  1. Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, Maastricht, Netherlands.
  2. Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
  3. Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
  4. Department of Medical Microbiology, Research School CAPHRI, Maastricht University Medical Centre, Maastricht, Netherlands.

PMID: 32676498 PMCID: PMC7333246 DOI: 10.3389/fbioe.2020.00634

Abstract

The one-stage treatment of chronic osteomyelitis with S53P4 bioactive glass (BAG) granules has shown excellent results. However, these granules possess suboptimal handling properties. Therefore, new injectable S53P4 putty materials have been developed by the incorporation of a synthetic binder to contain glass granules. The goal of the current study was to assess their potential to eradicate five clinically relevant pathogens:

Copyright © 2020 Thijssen, van Gestel, Bevers, Hofmann, Geurts, van Loo and Arts.

Keywords: S53P4; S53P4 formulations; bacteria; bioglass; biomaterials; eradication

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